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ICSA Antibody

  • 中文名称：
    ICSA兔多克隆抗体
  • 货号：
    CSB-PA745216XA01SZB
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: ICSA antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 40.3 kDa
      Observed band size: 45 kDa
  • 其他：

产品详情

  • Uniprot No.：
    Q7BCK4
  • 基因名：
    ICSA
  • 别名：
    Outer membrane protein IcsA autotransporter [Cleaved into: Outer membrane protein IcsA; Outer membrane protein IcsA translocator] icsA virG CP0182
  • 反应种属：
    Shigella flexneri
  • 免疫原：
    Recombinant Shigella flexneri ICSA protein (311-547aa)
  • 免疫原种属：
    Shigella flexneri
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Protein G
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for bacterial spreading by eliciting polar deposition of filamentous actin (actin-based motility). Inside the host cell mediates nucleation and polymerization of actin molecules on the bacterial surface, which provides the propulsive force for intracellular movement and intercellular dissemination of the bacterium. During invasion of mammalian cells, triggers autophagy by binding to APG5L. Interaction with IcsB leads to escape from the autophagic host defense system. Also binds ATP and displays weak ATPase activity.
  • 基因功能参考文献：
    1. Identification of the H-NS and VirF-binding sites on the icsA promoter regions. PMID: 21724612
    2. Data identified a putative autochaperone region required for IcsA biogenesis, and our data suggest an additional region, not previously identified, is required for N-WASP recruitment. PMID: 18456802
  • 亚细胞定位：
    [Outer membrane protein IcsA autotransporter]: Periplasm.; [Outer membrane protein IcsA]: Secreted. Cell surface. Note=The alpha domain is localized as a cap over the old pole of the bacterial surface.; [Outer membrane protein IcsA translocator]: Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
  • 数据库链接：

    KEGG: sfl:CP0182