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ICA1 Antibody

  • 中文名称：
    ICA1兔多克隆抗体
  • 货号：
    CSB-PA12109A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ICA1 antibody at 2µg/ml + A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 55, 58 kDa
      Observed band size: 55 kDa
    • Western Blot
      Positive WB detected in: Mouse brain tissue
      All lanes: ICA1 antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 55, 58 kDa
      Observed band size: 55 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA12109A0Rb at dilution of 1:50
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ICA1 Polyclonal antibody
  • Uniprot No.：
    Q05084
  • 基因名：
    ICA1
  • 别名：
    69 kDa islet cell autoantigen antibody; Diabetes mellitus type I autoantigen antibody; ICA 1 antibody; Ica1 antibody; ICA69 antibody; ICA69_HUMAN antibody; ICAp69 antibody; Islet cell autoantigen 1 (69kD) antibody; Islet cell autoantigen 1 69kDa antibody; Islet cell autoantigen 1 antibody; Islet cell autoantigen 1 isoform antibody; Islet cell autoantigen p69 antibody; OTTHUMP00000200933 antibody; OTTHUMP00000200934 antibody; OTTHUMP00000200941 antibody; OTTHUMP00000200993 antibody; p69 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Islet cell autoantigen 1 protein (1-268AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ICA1 Antibody (CSB-PA12109A0Rb)，的标记方式是Non-conjugated。对于ICA1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA12109B0Rb ICA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA12109C0Rb ICA1 Antibody, FITC conjugated
    Biotin CSB-PA12109D0Rb ICA1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in neurotransmitter secretion.
  • 基因功能参考文献：
    1. C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCalpha complex and cerebellar plasticity. PMID: 24358315
    2. Novel association was found between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1. PMID: 23836780
    3. polymorphisms within the NOD Ica1 core promoter may determine AIRE-mediated down-regulation of ICA69 expression in medullary thymic epithelial cells. PMID: 22447927
    4. The exon A promoter exhibits greater activity in islet cells, whereas the exon B promoter more efficiently activates transcription in neuronal cells. PMID: 12409289
    5. ICA69 as a novel Rab2 effector and its role in regulating the early transport of insulin secretory granule proteins PMID: 18187231

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  • 亚细胞定位：
    Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.
  • 组织特异性：
    Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.
  • 数据库链接：

    HGNC: 5343

    OMIM: 147625

    KEGG: hsa:3382

    STRING: 9606.ENSP00000379908

    UniGene: Hs.487561