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  4. HTRA1 Antibody

HTRA1 Antibody

  • 货号：
    CSB-PA010901GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q92743
  • 基因名：
    HTRA1
  • 别名：
    ARMD7 antibody; CARASIL antibody; High-temperature requirement A serine peptidase 1 antibody; HtrA antibody; HtrA serine peptidase 1 antibody; HTRA1 antibody; HTRA1_HUMAN antibody; IGFBP5 protease antibody; L56 antibody; ORF480 antibody; Protease serine 11 (IGF binding) antibody; protease serine 11 antibody; PRSS11 antibody; Serine protease 11 antibody; Serine protease HTRA1 antibody; Serine protease HTRA1 precursor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HTRA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
  • 基因功能参考文献：
    1. Nuclear downregulation of HtrA1 is associated with a better prognosis in women with high grade serous ovarian carcinoma. PMID: 30131069
    2. Case Report: Novel compound heterozygous mutations in HTRA1 causing CARASIL in Chinese patient. PMID: 30068478
    3. regulates odontoblastic differentiation of dental pulp cells through activation of the TGF-beta1/Smad signaling pathway PMID: 29580722
    4. the aberrant expression of HTRA1 or HTRA4 may be involved in the onset of preeclampsia, and increased HTRA1 or HTRA4 expression may affect trophoblast functions. PMID: 30015931
    5. HtrA1 contributes to the development of keloid lesions as matrix protease by remodelling keloid-specific ECM or cell surface molecules. PMID: 29695130
    6. Studies indicate a significantly different high-temperature requirement factor A1 (HtrA1) expression in cancer and non-cancer tissue [Meta-analysis]. PMID: 29409460
    7. HtrA1 overexpression further leads to impaired apical processes and decreased phagocytosis, an essential function for photoreceptor survival. PMID: 29269042
    8. Results suggest that HTRA1 is involved in the pathogenesis of scars through regulating activation of latent TGF-beta1 in keloid fibroblasts. PMID: 29412803
    9. the CADASIL-like family disease may be caused by heterozygous HTRA1 gene mutation, which leads to autosomal dominant hereditary cerebral small vessel disease. PMID: 29561953
    10. Case Report/Review: novel missense mutation in HTRA1 associated with phenotype of CARASIL. PMID: 28628911
    11. The rs11200638-rs2672598 joint genotype AA-CC conferred higher risk to exudative exudative age-related macular degeneration (AMD) than polypoidal choroidal vasculopathy (PCV). PMID: 27338780
    12. a possible proteolytic processing mechanism of mutant TGFBIp by HTRA1 and peptides generated by mutant protein may form the beta-amyloid core of corneal aggregates in Corneal dystrophic patients. PMID: 28689406
    13. HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective PMID: 27379525
    14. The observation of this study further supports the pathogenic role of the heterozygous HTRA1 mutations in familial cerebral small vessel disease. PMID: 28782182
    15. These findings suggest that the variation in the risk for age-related macular degeneration associated with chromosome 10q26 is likely due to variation in HTRA1 expression. PMID: 28659708
    16. HtrA1 role in the cisplatin resistance in colon cancer PMID: 28667026
    17. HtrA1 could serve as a marker to identify ulcerative colitis of >10 year duration patients at high risk of developing colorectal cancer. PMID: 28586045
    18. To our knowledge, this is the first time the association between rs11200638 and overall age-related macular degeneration has been reported in South America. PMID: 28846052
    19. because the ARMS2/HTRA1 genes are positioned at a locus on chromosome 10q26 in a region with strong linkage disequilibrium, it is difficult to distinguish the functions of the individual genes. a review of recent epidemiological studies of Age-related macular degeneration(AMD) is offered. An argument for a definite correlation between the ARMS2 gene and AMD is presented PMID: 28583181
    20. The expression of HtrA1 was strongly related to the T2 value, suggesting that HtrA1 plays an important role in the pathological process of intervertebral disc degeneration. PMID: 28432852
    21. These results suggest that the initiation stage of polypoidal choroidal vasculopathy is mediated by proteolytic degradation of extracellular matrix proteins attributable to increased HTRA1 activity PMID: 28941979
    22. The findings of the present study provide evidence that CFH gene variants and ARMS2/HTRA1 genes play a major role in the genetic susceptibility to AMD in a Greek population. These findings are of direct relevance for disease and help mapping the genetic chart of AMD. PMID: 26848857
    23. The function of the binding between MIF and HTRA1 is to inhibit the proteolytic activity of HTRA1. PMID: 28726057
    24. Results show that HTRA1 is epigenetically silenced in HCT116 colon carcinoma cells and during early stages of tumorigenesis in a mouse model of intestinal cancer. Downregulation of HTRA1 causes a multiple phenotypes that are hallmarks of cancer cells including increased proliferation of mouse embryonic fibroblasts, as well as chromosome and centrosome amplifications. PMID: 27388476
    25. High HTRA1 expression is associated with cervical cell proliferation. PMID: 27809811
    26. Data indicate HtrA serine peptidase 1 (HTRA1) involvement in Age-related macular degeneration (AMD) pathogenesis. PMID: 27841854
    27. Variants in HTRA1 are not associated with age-related macular degeneration. PMID: 27879347
    28. Results show the heterozygous missense mutations p.G283E, p.P285L, p.R302Q, and p.T319I in the HTRA1 gene in 8 patients with symptomatic cerebral small vessel disease; mutant HTRA1s observed in manifesting heterozygotes might result in an impaired HTRA1 activation cascade of HTRA1 or be unable to form stable trimers PMID: 27164673
    29. FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation PMID: 28076935
    30. correlation between TGFb1 and pSmad2 as well as between HtrA1 and TGFb1 and the very significant increase of Ki67 in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 in the pathogenesis of endometriosis. PMID: 26708185
    31. Two synonymous polymorphisms in exon 1 of the HTRA1 gene result in a protein with altered thermophoretic properties. PMID: 26310622
    32. significant increase of serum HtrA1 in early-onset pre-eclampsia PMID: 26187609
    33. a frameshift mutation in the HTRA1 gene detected in a CARASIL pedigree resulted in reduced HTRA1 protein and increased TGF-beta1 expression, which may cause severe CARASIL and peripheral small arterial disease PMID: 25772074
    34. Human HTRA1 expression is enhanced by Age-related macular degeneration specific indel mutation in the promoter region of HTRA1 gene, and this enhanced HTRA1 may be concerned with induce retinal neovasucularization. PMID: 27125063
    35. Results does not conclusively support HTRA1 role as a tumor suppressor but suggest its possible prognostic role in many human tumors. PMID: 26035313
    36. Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2, and HTRA1 with high linkage disequilibrium. PMID: 26427389
    37. Low HtrA1 expression is associated with gastric cancer. PMID: 25761858
    38. HtrA1 expression was closely related to EMT, which might be a potential mechanism underlying metastasis of HCC PMID: 26403966
    39. Low HtrA1 expression is significantly related to breast cancer poor prognosis parameters, and HtrA1 loss in sentinel nodes is related to metastasis of non sentinel nodes. PMID: 25530301
    40. It was concluded that high expression of HtrA1 could significantly reverse multidrug resistance of hepatoma cells by targeting XIAP. PMID: 25776486
    41. The growth of choroidal neovascularization in AMD would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2/HTRA1, a well-known susceptibility gene for AMD. PMID: 26337002
    42. HtrA1 appeared as an immunohistochemical marker to predict behaviour of the meningioma, mainly the recurrence PMID: 25687108
    43. HtrA1 plays a positive role in human periodontal ligament cells osteogenic differentiation and may regulate this process by TGFB1. PMID: 25726184
    44. In this study, we found that the interaction of ARMS2 and ARMS2/HTRA1 is significantly associated with nAMD, and the interaction of CFH and ARMS2 is pronounced in PCV development in Chinese population. PMID: 25771815
    45. HtrA1 expression in plasma cells could be correlated with the destruction of pathological periodontal tissue. PMID: 24979214
    46. Central but not peripheral drusen location was strongly associated with both [CFH HTRA1] and [CFH HTRA1]. Only [CFH HTRA1] was significantly associated with increased central drusen area. PMID: 25627090
    47. heterozygous HTRA1 mutations are an important cause of familial small vessel disease PMID: 26063658
    48. Silence of the HTRA1 gene was associated with significantly higher levels of TGF-beta1, BMP4, and BMP2 mRNA and reduction in the proliferation and migration of ARPE-19 cells. PMID: 25550099
    49. Gene variants in CFH, ARMS2 and HTRA1 are related to an increased risk of age-related macular degeneration in a northern Chinese population. PMID: 24865190
    50. alpha-1-antitrypsin as substrate of HTRA1 synthetic PMID: 25329061

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  • 相关疾病：
    Macular degeneration, age-related, 7 (ARMD7); Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy (CARASIL); Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, 2 (CADASIL2)
  • 亚细胞定位：
    Cell membrane. Secreted. Cytoplasm, cytosol.
  • 蛋白家族：
    Peptidase S1C family
  • 组织特异性：
    Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up-regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level).
  • 数据库链接：

    HGNC: 9476

    OMIM: 600142

    KEGG: hsa:5654

    STRING: 9606.ENSP00000357980

    UniGene: Hs.501280