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  4. HSPBP1 Antibody

HSPBP1 Antibody

  • 货号：
    CSB-PA010845GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NZL4
  • 基因名：
  • 别名：
    1500019G21Rik antibody; FES1 antibody; Heat shock protein 70 binding protein antibody; Heat shock protein 70 interacting protein antibody; Heat shock protein binding protein 1 antibody; Heat shock protein-binding protein 1 antibody; Heat-shock 70-KD protein-binding protein 1 antibody; HPBP1_HUMAN antibody; Hsp 70 binding protein antibody; Hsp 70 interacting protein antibody; Hsp70 binding protein 1 antibody; Hsp70 binding protein 2 antibody; Hsp70 interacting protein 1 antibody; Hsp70 interacting protein 2 antibody; Hsp70-binding protein 1 antibody; Hsp70-binding protein 2 antibody; Hsp70-interacting protein 1 antibody; Hsp70-interacting protein 2 antibody; HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 antibody; HSPA-binding protein 1 antibody; HSPBP antibody; HspBP1 antibody; HspBP2 antibody; PP1845 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HSPBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
  • 基因功能参考文献：
    1. Findings indicate a critical role of HspBP1 in differential CHIP/Hsp70 activities in neuronal and glial cells and the greater neuronal vulnerability to misfolded proteins in neurodegenerative diseases. PMID: 28847953
    2. downregulation of Hsp70 and HspBP1 represents a unique feature of patients with preterm prelabor rupture of membranes PMID: 28497897
    3. our results clearly show that HspBP1 acts as an endogenous negative regulator of HIV-1 gene-expression and replication by suppressing NF-kappaB-mediated activation of viral transcription. PMID: 26538602
    4. Oxidative stress, inducing formation of disulfide bond, can affect stability and conformational mobility of human HspB1. PMID: 24898092
    5. BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes PMID: 24454860
    6. shown that HspBP1 binds Tag7 in the conditioned medium of tumor CSML0 cells, thereby preventing formation of the cytotoxic Tag7-Hsp70 complex PMID: 22037021
    7. High gene expression of HspBP1 is associated with leukemia. PMID: 20694586
    8. Results report cooperative interactions involving Hsp70, Hsp40, and TPR1 that enhance Hsp70-dependent folding of chemically denatured substrates. PMID: 14503850
    9. Detection of hsp70 may be used as the screening marker for diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer related lung cancer, and may supplement the diagnostic value of conventional cytology. PMID: 14761400
    10. BAG2 binds to the carboxyl terminus of Hsp70-interacting protein (CHIP) and provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP PMID: 16169850
    11. The results demonstrate that Hsp70 and HspBP1 are not coordinately regulated but provide evidence that an increase in the ratio of HspBP1 to Hsp70 correlates with apoptosis, in a similar way to reducing the amount of Hsp70. PMID: 16677834
    12. Stress-induced heat shock protein 70 (Hsp70) effectively protects cells against ultraviol ray-induced apoptosis in melanocytes bu penetrating mitchondrial and lysosomal membranes. PMID: 16950797
    13. Here, we report that upon the formation of huntingtin aggregates; endogenous cytosolic huntingtin, Hsc70/Hsp70 (heat shock protein and cognate protein of 70kDa) and syntaxin 1A become aggregate-centered. PMID: 17208201
    14. that HspBP1, by antagonizing the prosurvival activity of Hsp70, sensitizes tumor cells to cathepsin-mediated cell death. PMID: 17855353
    15. Association between endogenous LAP2alpha and Hsp70 in non-transfected cells was confirmed by co-immunoprecipitation. PMID: 18261988
    16. The two chaperones, HSP72 and HSPBP1, interact both physically and functionally, leading to the activation of th EGFR-ERK1/2 signalling pathway. PMID: 18986301
    17. Results indicate that low HspBP1 expression could be a marker of tumor aggressiveness. PMID: 18987994
    18. Our data suggest that HIP may prevent inclusion formation by facilitating the constitutive HSC70 refolding cycle and possibly by preventing aggregation. PMID: 19183265
    19. HspBP1 may play a role in tumor (dys)regulation of chaperone proteins PMID: 19659607
    20. The cochaperone HspBP1 binds to and inhibits Hsp70 activity. PMID: 9830037

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  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 24989

    OMIM: 612939

    KEGG: hsa:23640

    STRING: 9606.ENSP00000255631

    UniGene: Hs.53066