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HSPB11 Antibody

  • 货号：
    CSB-PA010834GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y547
  • 基因名：
    HSPB11
  • 别名：
    Chromosome 1 open reading frame 41 antibody; Heat shock protein beta-11 antibody; HSB11_HUMAN antibody; Hspb11 antibody; HSPCO34 antibody; IFT25 antibody; Placental protein 25 antibody; PP25 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HSPB11
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation.
  • 基因功能参考文献：
    1. HSPB11 was identified as a novel prognostic marker in patients with high-grade glioma. PMID: 26544773
    2. HSPB11 are induced during multiple sclerosis lesion development in white but not grey matter. PMID: 26694816
    3. These data suggest that Hsp16.2 can prevent the destabilization of mitochondrial membrane systems and could represent a suitable target for modulating cell death pathways. PMID: 17275951
    4. Hsp16.2 expression is directly correlated with the histological grade of brain tumors. PMID: 18154656
  • 亚细胞定位：
    Cell projection, cilium.
  • 蛋白家族：
    IFT25 family
  • 组织特异性：
    Detected in placenta.
  • 数据库链接：

    HGNC: 25019

    KEGG: hsa:51668

    STRING: 9606.ENSP00000194214

    UniGene: Hs.525462