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HSPA1L Antibody

  • 货号：
    CSB-PA010823GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P34931
  • 基因名：
  • 别名：
    Heat shock 70 kDa protein 1 Hom antibody; Heat shock 70 kDa protein 1 like antibody; Heat shock 70 kDa protein 1-Hom antibody; Heat shock 70 kDa protein 1-like antibody; Heat shock 70 kDa protein 1L antibody; Heat shock 70kD protein like 1 antibody; HS71L_HUMAN antibody; HSP70 1L antibody; HSP70 HOM antibody; HSP70-Hom antibody; HSPA1L antibody; hum70t antibody; Spermatid specific heat shock protein 70 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HSPA1L
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.
  • 基因功能参考文献：
    1. HSP70-HOM gene polymorphism associated with susceptibility to noise-induced hearing loss. PMID: 29072670
    2. In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations. PMID: 28291257
    3. A heterozygous de novo mutation (c.830C > T; p.Ser277Leu) in HSPA1L in ulcerative colitis patient. Five additional rare HSPA1L mutations (p.Gly77Ser, p.Leu172del, p.Thr267Ile, p.Ala268Thr, p.Glu558Asp) were found in six other patients. All six rare HSPA1L variant proteins showed decreased chaperone activity in vitro. Moreover, three variants demonstrated dominant negative effects on HSPA1L and HSPA1A protein activity. PMID: 28126021
    4. Polymorphism of HSPA1L gene is associated with the development of esophageal Carcinoma. PMID: 26745065
    5. may be a predictive biomarker for chronic graft-versus-host disease following allogeneic stem cell transplantation PMID: 25680846
    6. HSPA1L (rs2227956) is associated with a decreased risk of idiopathic pulmonary fibrosis in a Mexican population. PMID: 26496868
    7. Infertility in males with normal sperm parameters was not significantly associated with HSPA1L:c.1478C>T gene polymorphism. PMID: 26160076
    8. HSP70-hom polymorphisms modify the association of diethylhexyl phthalates exposure with insulin resistance. PMID: 25044062
    9. In HSPA1L T2437C polymorphisms, there was no significant differences in frequencies of the variant homozygous in patients compared to controls. PMID: 23666708
    10. findings show polymorphisms of HSP70 genes are associated with the development of gastric cancer and duodenal ulcers in a population at high risk for gastric cancer in Costa Rica PMID: 24051039
    11. studied the relationship between blood levels of HSP70 and HSP90 and genotypes of HSP70, GSTT1, and GSTM1 polymorphic variants in individuals chronically exposed to mercury PMID: 23330093
    12. HSP70-hom gene polymorphism may have a role in graft-versus-host disease after hematopoietic stem cell transplantation PMID: 17060867
    13. examined the relationship between the HSP70-hom polymorphism and the clinical characteristics of the malignancy at the time of diagnosis PMID: 17578680
    14. A strong association was found between HSP-70/Hom rs2075800 G and uveitis in patients with sarcoidosis. PMID: 17591867
    15. polymorphisms in HSP70-HOM genes associated with noise-induced hearing loss PMID: 18813331

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  • 蛋白家族：
    Heat shock protein 70 family
  • 组织特异性：
    Expressed in spermatids.
  • 数据库链接：

    HGNC: 5234

    OMIM: 140559

    KEGG: hsa:3305

    STRING: 9606.ENSP00000364805

    UniGene: Hs.690634