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HSF2 Antibody

  • 货号：
    CSB-PA987633
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA987633(HSF2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q03933
  • 基因名：
    HSF2
  • 别名：
    Heat shock factor protein 2 antibody; Heat shock transcription factor 2 antibody; HSF 2 antibody; HSF2 antibody; HSF2_HUMAN antibody; HSTF 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human HSF2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
  • 基因功能参考文献：
    1. Silencing ALG3 or HSF2 inhibited the proliferation, migration, and invasion abilities of MCF-7 cells. PMID: 29799832
    2. HSF2 is a direct target of miR202 with a binding site on 3'-UTR of HSF2 mRNA in esophageal squamous cell carcinoma cells. PMID: 28277193
    3. This study provides the first evidence for HSF2 acting as a suppressor of invasion in human malignancies. PMID: 26119944
    4. Presented are the crystal structures of the human HSF2 DNA-binding domain (DBD) bound to DNA. PMID: 26727490
    5. the findings of our studys suggest that HSF2 contributes to its own expression by forming a negative autoregulatory loop. PMID: 26260034
    6. HSF2 can induce histone activation.Set1/MLL complex is indispensable for the transcriptional ability of HSF2. PMID: 26478434
    7. HSF2 appears to be a potential novel molecular marker for ulcerative colitis PMID: 24533153
    8. the condensed chromatin of HSF2-deficient cells is accessible for HSF1 and RNA polymerase II, allowing stress-inducible Hsp expression. PMID: 25202032
    9. These results support a role for HSF2 in the pathogenesis of IA and further implicate this transcription factor as a potential therapeutic target. PMID: 23064888
    10. our findings suggest novel mechanisms of HSF2 regulation controlled by HSF4a. PMID: 21792930
    11. Data show that the PEST sequences of a short-lived protein called HSF2 interact with Cullin3, a subunit of a Cullin-RING E3 ubiquitin ligase, and that this interaction mediates the Cul3-dependent ubiquitination and degradation of HSF2. PMID: 19768582
    12. characterization of the hsf2 gene and its 5'-flanking region PMID: 11795475
    13. HSF2 influences to the formation of nuclear stress granules PMID: 12865437
    14. HSF1 has a role in transcriptional regulation of the human RANK ligand gene PMID: 14699143
    15. results show hsp70i bookmarking is mediated by HSF2 which binds this promoter in mitotic cells, recruits protein phosphatase 2A & interacts with the CAP-G subunit of condensin to promote dephosphorylation & inactivation of condensin complexes PMID: 15662014
    16. The results of these experiments indicate that the HSF2 region comprising amino acids 343-363 is important for A subunit interaction. PMID: 17688198
    17. During mitosis, HSF2 is bound to the HSE promoter elements of other heat shock genes, including hsp90 and hsp27, and the proto-oncogene c-fos. The presence of HSF2 is important for expression of these genes. PMID: 17915561
    18. MEL-18 bound to HSF2 inhibits its sumoylation by binding to and inhibiting the activity of UBC9 enzymes in the vicinity of HSF2. PMID: 18211895
    19. These results provide a potential mechanistic basis for the defective cytokinesis phenotype exhibited by HSF2-/- cells, as well as suggest a potential role for PRC1 in HSF2-mediated gene bookmarking. PMID: 18570919
    20. NMR study of the SUMOylated DNA binding domain of HSF2 indicates that the SUMO moiety is flexible with respect to the DNA binding domain and has neither a noncovalent interface with nor a structural effect on the domain PMID: 19017645
    21. HSF1-HSF2 heterotrimerization regulates stress-induced transcription PMID: 19129477

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
  • 蛋白家族：
    HSF family
  • 数据库链接：

    HGNC: 5225

    OMIM: 140581

    KEGG: hsa:3298

    STRING: 9606.ENSP00000357440

    UniGene: Hs.158195