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HS3ST1 Antibody

  • 货号：
    CSB-PA010747GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14792
  • 基因名：
    HS3ST1
  • 别名：
    3-OST-1 antibody; 3OST antibody; 3OST1 antibody; EC 2.8.2.23 antibody; h3 OST 1 antibody; h3-OST-1 antibody; Heparan sulfate (glucosamine) 3 O sulfotransferase 1 antibody; Heparan sulfate 3 O sulfotransferase 1 antibody; Heparan sulfate 3-O-sulfotransferase 1 antibody; Heparan sulfate D glucosaminyl 3 O sulfotransferase 1 antibody; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1 antibody; Heparan sulfate glucosamine 3-O-sulfotransferase 1 antibody; Heparin glucosamine 3 O sulfotransferase antibody; HS3S1_HUMAN antibody; HS3ST 1 antibody; Hs3st1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HS3ST1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.
  • 基因功能参考文献：
    1. Compared with Hs3st1+/+ mice, Hs3st1-/- mice were more susceptible to LPS-induced death due to an increased sensitivity to TNF PMID: 28126521
    2. Golgi-targeted HS3st1 localizes in the Golgi and results in the formation of a single type of AT-binding site and high anti-factor Xa activity PMID: 24247246
    3. In this paper a conformational change is described that occurs in heparan sulfate 3-O-sulfotransferase-1 upon binding to heparan sulfate. PMID: 15096036
  • 亚细胞定位：
    Golgi apparatus lumen.
  • 蛋白家族：
    Sulfotransferase 1 family
  • 组织特异性：
    Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta.
  • 数据库链接：

    HGNC: 5194

    OMIM: 603244

    KEGG: hsa:9957

    STRING: 9606.ENSP00000002596

    UniGene: Hs.507348