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HOXC8 Antibody

  • 货号：
    CSB-PA947837
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA947837(HOXC8 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA947837(HOXC8 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P31273
  • 基因名：
    HOXC8
  • 别名：
    Homeo box 3A antibody; Homeo box 8 antibody; Homeobox 3A antibody; Homeobox C8 antibody; Homeobox protein Hox C8 antibody; Homeobox protein Hox-3A antibody; Homeobox protein Hox-C8 antibody; Homeobox protein HoxC8 antibody; Homeobox protein R4 antibody; Homolog of mouse Hox 3.1 antibody; HOX 3 antibody; Hox 3.1 mouse homolog of antibody; HOX 3A antibody; HOX C8 antibody; Hox-3.1 antibody; Hox-3A antibody; HOX3 antibody; HOX3A antibody; HOXC 8 antibody; Hoxc-8 antibody; HOXC8 antibody; HXC8_HUMAN antibody; M31 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human HOXC8
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. Results show that HOXC8 is consistently downregulated in stem/progenitor cells of all breast molecular subtypes, thus representing a putative tumor suppressor candidate. Also, downregulated expression of HOXC8 is associated with DNA methylation at the gene promoter and expression of miR196 family members. Taken together, study establishes HOXC8 as a suppressor of stemness and transformation in the mammary gland lineage. PMID: 28202042
    2. Owing to the overexpression of Homeobox C8 (HOXC8), findings implied that HOXC8 is involved in the progression of epithelial ovarian cancer (EOC) and could be a potential therapeutical approach of EOC. PMID: 26763553
    3. High expression of HOXC8 is associated with laryngeal squamous cell carcinoma. PMID: 27658780
    4. HOXC8 knockdown led to inhibition of tumor cell proliferation and migration in vitro by inhibiting MMP-9 expression and tumor growth in vivo. The results strongly suggest that HOXC8 is involved in the tumorigenesis of osteosarcoma and might serve as a novel predictor for patients' outcome. PMID: 27651160
    5. embigin is regulated by HOXC8 and its loss plays an important role in the progression of breast tumors PMID: 26090721
    6. Ectopic expression of HoxC8 inhibits nasopharyngeal carcinoma cell growth in vitro and in vivo, modulates glycolysis and regulates the expression of tricarboxylic acid (TCA) cycle-related genes. PMID: 25745994
    7. Upregulated HOXC8 expression was associated with oxaliplatin resistance in hepatocellular carcinoma. PMID: 26123838
    8. miR-196a was over-expressed in cervical cancer cells, while an absence of HOXC8 expression was observed. PMID: 24817935
    9. HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression. PMID: 24810778
    10. HOXC8 can be used as a prognostic marker in esophageal squamous cell carcinoma PMID: 24525058
    11. HOXC8 expression is inversely related to pancreatic ductal adenocarcinoma progression and metastasis. PMID: 21712827
    12. a complex role for HOXC8 in prostate cancer, promoting invasiveness while inhibiting AR-mediated gene induction at androgen response element-regulated genes associated with differentiated function of the prostate PMID: 21047772
    13. Ratio of microRNA to HOXC8 mRNA may be an indicator of the metastatic capability of breast tumors. PMID: 20736365
    14. overexpression associated with loss of tumor differentiation in human prostate cancer; may play role in acquisition of invasive/metastatic phenotype PMID: 11813208
    15. Androgen-independent cell line DU145 cells lack PLZF gene expression, resulting in the upregulation of Pbx1 and HoxC8 expression. The Pbx1-HoxC8 heterocomplex may lead to androgen-independent growth in prostate cancer. PMID: 16637071

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    HGNC: 5129

    OMIM: 142970

    KEGG: hsa:3224

    STRING: 9606.ENSP00000040584

    UniGene: Hs.664500