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HOXB5 Antibody

  • 货号：
    CSB-PA010665ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Homeobox protein Hox-B5 antibody at 8μg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: Rat liver tissue
      Lane 3: Rat lung tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 29 kDa
      Observed band size: 29 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA010665ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HOXB5 Polyclonal antibody
  • Uniprot No.：
    P09067
  • 基因名：
    HOXB5
  • 别名：
    HGNC:5116 antibody; HHO.C10 antibody; Homeo box 2A antibody; Homeo box B5 antibody; Homeobox 2A antibody; Homeobox B5 antibody; Homeobox protein HHO.C10 antibody; Homeobox protein Hox B5 antibody; Homeobox protein Hox-2A antibody; Homeobox protein Hox-B5 antibody; Homeobox protein HoxB5 antibody; Homeobox protein Hu-1 antibody; Homeobox2A antibody; HomeoboxB5 antibody; HOX 2 antibody; Hox 2.1 antibody; HOX 2A antibody; HOX B5 antibody; HOX2 antibody; Hox2.1 antibody; Hox2.1, mouse, homolog of antibody; HOX2A antibody; HOXB 5 antibody; Hoxb5 antibody; HU 1 antibody; HU1 antibody; HXB5_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Homeobox protein Hox-B5 protein (1-170AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. for the first time we have shown that knockdown of HOXB5 significantly inhibited non-small cell lung cancer cell proliferation, invasion, metastasis, and epithelial-mesenchymal transformation, partly through the Wnt/beta-catenin signaling pathway PMID: 28337958
    2. Taken together, our results for the first time suggested that miR-455-3p was downregulated in NSCLC and was correlated with the poor prognosis of NSCLC patients. Also, miR-455-3p functions as tumor suppressor by directly targeting HOXB5 in NSCLC progression and may be used as a potential target for NSCLC treatment. PMID: 29170127
    3. HOXB5 acts as a positive modulator by promoting cell proliferative response and invasiveness in ER-positive breast cancer. PMID: 25999793
    4. HOXB5 may be an important regulator of the Wnt/beta-catenin signalling pathway, thereby contributing to gastric cancer progression and metastasis. PMID: 26467157
    5. Roles of Hoxb5 in the development of vagal and trunk neural crest cells. PMID: 25703667
    6. Overexpression of HoxB5 enhances blood vessel perfusion in vivo by up-regulation of MCP-1 and IL-6 as well as in enhanced leucocyte infiltration and blood vessel remodelling. PMID: 24189625
    7. HOXB5 and HOXB8 are frequently expressed in ovarian serous carcinoma, with anatomic site-related differences for cytoplasmic staining. HOXB5 may be affected by chemotherapy in effusions. PMID: 23438671
    8. The findings for HOXB5 and PHOX2B provide supportive evidence that genes regulating ENCC proliferation, migration and differentiation could be risk factors for Hirschsprung's disease PMID: 22648184
    9. A miRNA 7-binding single nucleotide polymorphism (1010A/G) located within 3'-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. PMID: 22768238
    10. HOXB5, HOXB6, and HOXB7 are activated in Barrett esophagus, and the midcluster HOXB gene signature in BE most resembled the colon rather than other GI epithelia. PMID: 22603795
    11. Single nucleotide polymorphism in HOXB5 gene is associated with childhood obesity. PMID: 22484627
    12. results support that expression of HOX genes is associated with oral squamous cell carcinoma; over 90% of OSCC samples presented HOXB5 expression versus 60% of non-tumor tissues, it can be suggested that HOXB5 may be related to the malignant phenotypes. PMID: 21552713
    13. Data show that human HOXB5 binds to the promoter region 5' upstream of the binding site of NKX2-1 and regulates RET expression. PMID: 21677782
    14. HoxB5 is necessary and sufficient to activate the cell-intrinsic events that regulate the differentiation of angioblasts and mature endothelial cells from their mesoderm-derived precursors PMID: 12897140
    15. The expression pattern of HOXB5 correlated with the migration and differentiation of neural crest cells. PMID: 12950074

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 组织特异性：
    Spinal cord.
  • 数据库链接：

    HGNC: 5116

    OMIM: 142960

    KEGG: hsa:3215

    STRING: 9606.ENSP00000239151

    UniGene: Hs.654456