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HOXB3 Antibody

  • 货号：
    CSB-PA010663LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA010663LA01HU diluted at 1:600 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HOXB3 Polyclonal antibody
  • Uniprot No.：
    P14651
  • 基因名：
    HOXB3
  • 别名：
    Homeo box 2G antibody; Homeo box B3 antibody; Homeobox B3 antibody; Homeobox protein Hox-2.7 antibody; Homeobox protein Hox-2G antibody; Homeobox protein Hox-B3 antibody; Homeobox protein HoxB3 antibody; Hox 2.7 antibody; HOX 2G antibody; HOX2 antibody; Hox2.7 antibody; HOX2G antibody; HOXB3 antibody; HXB3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein Hox-B3 protein (315-423AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HOXB3 Antibody (CSB-PA010663LA01HU)，的标记方式是Non-conjugated。对于HOXB3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010663LB01HU HOXB3 Antibody, HRP conjugated ELISA
    FITC CSB-PA010663LC01HU HOXB3 Antibody, FITC conjugated
    Biotin CSB-PA010663LD01HU HOXB3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. Data indicate a miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry which contributes to leukemogenesis and suggest a therapeutic strategy of restoring miR-375 expression in Acute myeloid leukemia (AML). PMID: 29439669
    2. HOXB3 is degraded by miR-375 in breast cancer cells.HOXB3 plays role in tamoxifen resistance. PMID: 28075453
    3. miR-10b might control cell apoptosis, proliferation, migration, and invasion in endometrial cancer via regulation of HOXB3 expression. PMID: 27447302
    4. decreased methylation at HOXB3 and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML, while increased DNA methylation at DCC distinctive to the high-risk AML was associated with increased gene expression PMID: 25996682
    5. describe familial cases of TH in two generations (proband and his father), in addition to other two sporadic cases. We have found polymorphisms in the HOXB3, HOXD3, and a new synonymous variant, and PITX2 genes PMID: 24127533
    6. HoxB3 promote prostate cancer progression by upregulating CDCA3 expression. PMID: 23219899
    7. The HOXb3 was only weakly expressed in the inv(7) positive patients. PMID: 15674412
    8. RASSF1A silencing strongly correlates with overexpression of HOXB3 and DNMT3B. PMID: 19854132

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    HGNC: 5114

    OMIM: 142966

    KEGG: hsa:3213

    STRING: 9606.ENSP00000308252

    UniGene: Hs.654560