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HOXB2 Antibody

  • 货号：
    CSB-PA009247
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P14652
  • 基因名：
    HOXB2
  • 别名：
    homeo box 2H antibody; homeo box B2 antibody; homeobox B2 antibody; Homeobox protein Hox-2.8 antibody; Homeobox protein Hox-2H antibody; Homeobox protein Hox-B2 antibody; Hox 2 8 antibody; Hox 2H antibody; HOX2 antibody; HOX2H antibody; hoxb2 antibody; HXB2_HUMAN antibody; K8 antibody; K8 home protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human HoxB2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. HOXB2 and HOXB3 act as tumor suppressors in acute myeloid leukemia patients carrying the FLT3 protein mutations. PMID: 26482852
    2. Increased expression of HOXB2 protein is associated with HPV infection and cervical cancer progression. PMID: 25743797
    3. HOXB2 acts as a negative tumor growth regulator, decreasing proliferation in mammary adenocarcinoma tumors. PMID: 21672623
    4. hoxb2 and hoxb4 expression is related to erythroid hematopoiesis, and hoxb4 has greater relevance to erythroid hematopoiesis as compared with hoxb2. PMID: 20030938
    5. Downregulation of HoxB2, HoxB4 and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation. PMID: 20625746
    6. Hoxb2 is a direct target for regulation by PLZF in the developing CNS and suggest that deregulation of Hox gene expression may contribute to APL pathogenesis. PMID: 12802276
    7. HOXB2 up-regulated lesions to have much higher HOXB2 expression than the corresponding normal tissue. PMID: 17805056

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family, Proboscipedia subfamily
  • 数据库链接：

    HGNC: 5113

    OMIM: 142967

    KEGG: hsa:3212

    STRING: 9606.ENSP00000331741

    UniGene: Hs.514289