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HORMAD2 Antibody

  • 货号：
    CSB-PA836683LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA836683LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HORMAD2 Polyclonal antibody
  • Uniprot No.：
    Q8N7B1
  • 基因名：
    HORMAD2
  • 别名：
    4930529M09Rik antibody; CT46.2 antibody; HORM2_HUMAN antibody; HORMA domain containing 2 antibody; HORMA domain-containing protein 2 antibody; Hormad2 antibody; MGC26710 antibody; RP23-329P17.4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human HORMA domain-containing protein 2 protein (14-307AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HORMAD2 Antibody (CSB-PA836683LA01HU)，的标记方式是Non-conjugated。对于HORMAD2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836683LB01HU HORMAD2 Antibody, HRP conjugated ELISA
    FITC CSB-PA836683LC01HU HORMAD2 Antibody, FITC conjugated
    Biotin CSB-PA836683LD01HU HORMAD2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation.
  • 基因功能参考文献：
    1. The variant rs2412971, intronic in HORMAD2 at chromosome 22q12.2, was robustly associated with tonsillectomy. PMID: 27941131
    2. These findings indicate that polymorphisms at the CT gene HORMAD2 might be involved in the prognosis of advanced non-small-cell lung cancer in Han Chinese. PMID: 24797335
    3. HORMAD2 is predominantly expressed in human testis and weakly expressed in liver. HORMAD2 is ectopically expressed in nearly 10% of lung cancer samples from Chinese Han individuals. PMID: 22893617
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 组织特异性：
    Highly expressed in testis (at protein level). Expressed in lung adenocarcinoma and squamous cell carcinoma (at protein level). Expressed at lower levels in the liver, brain and kidney.
  • 数据库链接：

    HGNC: 28383

    KEGG: hsa:150280

    STRING: 9606.ENSP00000336984

    UniGene: Hs.120391