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HOPX Antibody

  • 货号：
    CSB-PA010643GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BPY8
  • 基因名：
    HOPX
  • 别名：
    CAMEO antibody; heart odd homeobox 1 protein antibody; HOD antibody; Homeodomain-only protein antibody; HOP antibody; HOP homeobox antibody; HOP_HUMAN antibody; HOPX antibody; LAGY antibody; Lung cancer-associated Y protein antibody; NECC1 antibody; Not expressed in choriocarcinoma clone 1 antibody; Not expressed in choriocarcinoma protein 1 antibody; OB1 antibody; odd homeobox 1 protein antibody; Odd homeobox protein 1 antibody; OTTHUMP00000158970 antibody; SMAP31 antibody; TOTO antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HOPX
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
  • 基因功能参考文献：
    1. Data suggest that HOP homeobox HOPX (HOPX) acts as a tumour suppressor via the epigenetic regulation of snail family transcription factors (SNAIL) transcription and a prognostic biomarker for nasopharyngeal carcinoma (NPC) metastasis and therapeutic target for NPC treatment. PMID: 28146149
    2. HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis PMID: 27934959
    3. The association between the MEEVD C-terminal peptide from the heat shock protein 90 (Hsp90) and tetratricopeptide repeat A (TPR2A) domain of the heat shock organizing protein (Hop) is a useful prototype to study the fundamental molecular details about the Hop-Hsp90 interaction. Observed are conformational changes of the peptide and the protein receptor induced by binding. The binding free energy is 8.4 kcal/mol. PMID: 28723223
    4. HOPX is functionally regulated by SCL in hematoendothelial differentiation of mesoderm progenitor cells. PMID: 28813672
    5. HOPX is a distinctive homeobox gene with characteristic clinical and biological implications and its expression is a powerful predictor of prognosis in AML patients. PMID: 28341738
    6. HOPX has a role in the pathogenesis of skin cancers and skin diseases. PMID: 27017330
    7. these data indicate that the disruption of the PrP(C)-HOP complex could be a potential therapeutic target for modulating the migratory and invasive cellular properties that lead to metastatic Colorectal cancer (CRC). PMID: 27112151
    8. HOPX promoter methylation is not only frequent and cancer-specific but also associated with aggressive phenotype in breast cancer. PMID: 27756570
    9. Computational results identified HOPX gene as a new potential driver for ovarian carcinogenesis. PMID: 27287041
    10. The results suggest that HOPX may contribute to pathogenesis or manifestation of hypertrophic cardiomyopathy as a modifier gene. PMID: 25036325
    11. Data show that binding of heat shock proteins Hsp70 and Hsp90 requires prior binding of Hop protein to Hsp90. PMID: 26286954
    12. HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer. PMID: 25345926
    13. GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype. PMID: 23707782
    14. HOPX-beta promoter methylation is a frequent and cancer-specific event in CRC progression. PMID: 22904674
    15. Knockdown of Hop caused a decrease in the level of RhoC GTPase, and significantly inhibited pseudopodia formation in Hs578T cells. Our data suggest that Hop regulates directional cell migration by multiple unknown mechanisms. PMID: 23036489
    16. HOPX/Hopx expression is reduced in multiple examples of human and murine cardiac hypertrophy and failure. PMID: 21382376
    17. results identify distinct functions for the Hop cochaperone, revealing an asymmetric mechanism for Hsp90 regulation and client loading PMID: 21700222
    18. HOP is a novel modulator of late terminal differentiation in keratinocytes PMID: 21256618
    19. Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas-induced apoptosis. PMID: 21061432
    20. HOPX-beta promoter methylation is a frequent and cancer-specific event in gastric cancer PMID: 20228841
    21. HOPX is modulated by cell differentiation in human keratinocytes and this might contribute to homeostasis of keratinocytes by controlling differentiation-dependent genes. PMID: 20226564
    22. Loss of NECC1 expression is involved in malignant conversion of placental trophoblasts. PMID: 12573257
    23. Gene mapping locates LAGY on chromosome 4q11-13.1. In 72 primary lung tumors, this gene was significantly down-regulated compared to 9 normal lung tissue samples. PMID: 12759545
    24. One role of Hop is to modify the expression of cardiac-specific genes and thereby finely regulate heart development. PMID: 14522464
    25. Decrease in homeodomain-only protein is associated with hypopharyngeal carcinoma PMID: 15213722
    26. SMAP31 expression is elevated in 4 of 6 papillary thyroid tumor samples compared to 4 normal thyroid controls. PMID: 15307938
    27. loss of NECC1 expression is involved in malignant conversion of placental trophoblasts PMID: 15457851
    28. Our results demonstrate that the homeodomain fold has been co-opted during evolution for functions other than sequence-specific DNA binding and suggest that HOP functions as an adaptor protein to mediate transcriptional repression. PMID: 16939210
    29. The data indicate that signaling induced by hop/STI-1 depends on endocytosis PMID: 17498662
    30. Gradual induction of HOP/NECC1 in response to differentiation stimuli may result in the decision to differentiate into a particular type of trophoblastic cell lineage and result in non-lethal defects PMID: 17576768
    31. HOP is a putative tumor suppressor gene that harbors tumor inhibitory activity. PMID: 18234960
    32. HOP may work as a tumor suppressor in a subset of glioblastomas; HOP function thus appears to be critical in the adult brain in a region of continued plasticity, and its deregulation may contribute to disease PMID: 18507846
    33. transcriptional silencing of HOPX results from hypermethylation of the HOPpromoter, which leads to human uterine endometrial cancers (HEC) development. PMID: 19173292

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma an
  • 数据库链接：

    HGNC: 24961

    OMIM: 607275

    KEGG: hsa:84525

    STRING: 9606.ENSP00000450527

    UniGene: Hs.619396