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  4. HNRNPUL1 Antibody

HNRNPUL1 Antibody

  • 中文名称：
    HNRNPUL1兔多克隆抗体
  • 货号：
    CSB-PA010616GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BUJ2
  • 基因名：
    HNRNPUL1
  • 别名：
    Adenovirus early region 1B associated protein 5 antibody; Adenovirus early region 1B-associated protein 5 antibody; E130317O14Rik antibody; E1B 55 kDa associated protein 5 antibody; E1B AP5 antibody; E1B-55 kDa-associated protein 5 antibody; E1B-AP5 antibody; E1BAP5 antibody; fb53d10 antibody; fk45c03 antibody; FLJ12944 antibody; Heterogeneous nuclear ribonucleoprotein U-like protein 1 antibody; HNRL1_HUMAN antibody; Hnrnpul1 antibody; HNRPUL1 antibody; MGC36621 antibody; MGC78330 antibody; wu:fb53d10 antibody; wu:fk45c03 antibody; zgc:85971 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HNRNPUL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.
  • 基因功能参考文献：
    1. we define the arginines within the RGG/RG motifs as the site of methylation by PRMT1 both in vitro and in vivo. The arginines within the human hnRNPUL1 RGG/RG motifs were substituted with lysines to generate hnRNPUL1(RK). PMID: 26020839
    2. U7 snRNP represses histone gene transcription under cell cycle-arrested conditions. hnRNP UL1 is responsible for U7 snRNP-dependent transcriptional repression of replication-dependent histone genes. PMID: 22451911
    3. Despite the limitations, hnRPUL1 and PARP1 were downregulated in renal cell carcinoma and connected with the prognosis. PMID: 24595077
    4. hnRPUL1 as a new component related to PARP1 in DNA damage response and repair PMID: 23577092
    5. hnRNPUL1 and -2 function downstream of MRN and CtBP-interacting protein (CtIP) to promote recruitment of the BLM helicase to DNA breaks. PMID: 22365830
    6. E1B-AP5 is a novel surface molecule that is involved in the undifferentiated state of human embryonic stem cells PMID: 21083500
    7. Regulation of transcripton by this protein is mediated by complex formation with BRD7 PMID: 12489984
    8. Variants in 2 genes were associated with early-onset myocardial infarct: VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein. PMID: 16690874
    9. Taken together, these results define a role for E1B-AP5 in ATR signaling pathways activated during adenovirus infection. PMID: 18480432
    10. Human E1B-AP5 binds to adenovirus E1B-55kDa protein. PMID: 9733834

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 17011

    OMIM: 605800

    KEGG: hsa:11100

    STRING: 9606.ENSP00000375863

    UniGene: Hs.155218