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HNRNPDL Antibody

  • 货号：
    CSB-PA080117
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O14979
  • 基因名：
    HNRNPDL
  • 别名：
    A+U-rich element RNA binding factor antibody; AA407431 antibody; AA959857 antibody; AU rich element RNA binding factor antibody; AU-rich element RNA-binding factor antibody; D5Ertd650e antibody; D5Wsu145e antibody; Heterogeneous nuclear ribonucleoprotein D like antibody; Heterogeneous nuclear ribonucleoprotein D like protein antibody; Heterogeneous nuclear ribonucleoprotein D-like antibody; hnHNRP DL antibody; HNRDL_HUMAN antibody; HNRNP antibody; hnRNP D-like antibody; hnRNP DL antibody; HNRNPDL antibody; hnRPD like protein antibody; JKT41 binding protein antibody; JKT41-binding protein antibody; JKTBP antibody; JKTBP2 antibody; laAUF1 antibody; MGC125262 antibody; Protein laAUF1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human hnRNP DL.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.
  • 基因功能参考文献：
    1. Heterogeneous nuclear ribonucleoprotein D-like (HNRPDL) is aberrantly expressed in specimens from colorectal cancer patients. PMID: 30052712
    2. Both hnRNP D and DL are able to control their own expression by alternative splicing of cassette exons in their 3'UTRs. Exon inclusion produces mRNAs degraded by nonsense-mediated decay. Moreover, hnRNP D and DL control the expression of one another by the same mechanism. PMID: 29263134
    3. A defect in the RNA-processing protein HNRPDL causes limb-girdle muscular dystrophy 1G. PMID: 24647604
    4. hnRNP DL and CNBP are novel antigens for SLE patients PMID: 23642268
    5. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    6. The results indicate that JKTBP1 regulates the level of NRF protein expression by binding to both NRF 5' and 3' UTRs. PMID: 21300069
    7. Study shows that there is interaction of the intracellular domain of beta-amyloid precursor protein with JKTBP2, indicating that JKTBP2 may have an important function in AD formation. PMID: 16011250
    8. The data of this study show that JKTBP1 and the 14-nt element act independently to mediate NRF internal ribosome entry segment activity. PMID: 17592041
    9. overexpression of JKTBP1 in LNCaP cells leads to abnormal cell proliferation PMID: 18381662

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  • 相关疾病：
    Limb-girdle muscular dystrophy 1G (LGMD1G)
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibro
  • 数据库链接：

    HGNC: 5037

    OMIM: 607137

    KEGG: hsa:9987

    STRING: 9606.ENSP00000295470

    UniGene: Hs.527105