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HKDC1 Antibody

  • 货号：
    CSB-PA647983LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: HKDC1 antibody at 4µg/ml + U87 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 103, 91, 83 kDa
      Observed band size: 103 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA647983LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HKDC1 Polyclonal antibody
  • Uniprot No.：
    Q2TB90
  • 基因名：
  • 别名：
    BC016235 antibody; Hexokinase domain containing 1 antibody; Hexokinase domain-containing protein 1 antibody; Hkdc1 antibody; HKDC1_HUMAN antibody; Putative hexokinase HKDC1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Putative hexokinase HKDC1 protein (129-427AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HKDC1 Antibody (CSB-PA647983LA01HU)，的标记方式是Non-conjugated。对于HKDC1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA647983LB01HU HKDC1 Antibody, HRP conjugated ELISA
    FITC CSB-PA647983LC01HU HKDC1 Antibody, FITC conjugated
    Biotin CSB-PA647983LD01HU HKDC1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases. Has low glucose phosphorylating activity compared to other hexokinases. Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role.
  • 基因功能参考文献：
    1. results suggest a conditional regulation of KRT16 gene by ATF4 that may be inhibited in normal cells, but engaged during cancer progression. Potential roles of KRT16, FAM129A and HKDC1 genes upregulation in adaptive stress responses and pathologies are discussed PMID: 29420561
    2. Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family PMID: 27703147
    3. Association of HKDC1 genetic variants with susceptibility to gestational diabetes mellitus. PMID: 27346736
    4. Data identified two novel genome-wide significant associations: 2-h plasma glucose and HKDC1, and fasting C-peptide and BACE2. PMID: 23903356
  • 亚细胞定位：
    Mitochondrion membrane; Peripheral membrane protein.
  • 蛋白家族：
    Hexokinase family
  • 组织特异性：
    Widely expressed. Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines; the acinar centrocytes and interlobular ducts of the pancreas; and the alveolar macrophages in the lungs (at protein lev
  • 数据库链接：

    HGNC: 23302

    KEGG: hsa:80201

    STRING: 9606.ENSP00000346643

    UniGene: Hs.522988