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HJURP Antibody

  • 货号：
    CSB-PA010467LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: HJURP antibody at 12µg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 84, 78, 75 kDa
      Observed band size: 84 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) HJURP Polyclonal antibody
  • Uniprot No.：
    Q8NCD3
  • 基因名：
    HJURP
  • 别名：
    HJURP antibody; FAKTS antibody; FLEG1 antibody; URLC9 antibody; Holliday junction recognition protein antibody; 14-3-3-associated AKT substrate antibody; Fetal liver-expressing gene 1 protein antibody; Up-regulated in lung cancer 9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Holliday junction recognition protein (1-748AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，HJURP Antibody (CSB-PA010467LA01HU)，的标记方式是Non-conjugated。对于HJURP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010467LB01HU HJURP Antibody, HRP conjugated ELISA
    FITC CSB-PA010467LC01HU HJURP Antibody, FITC conjugated
    Biotin CSB-PA010467LD01HU HJURP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
  • 基因功能参考文献：
    1. Increased expression of HJURP was identified as an independent negative prognostic biomarker for patients with advanced serous ovarian cancer. PMID: 29743473
    2. during the CENP-A/H4 deposition process, the chaperone HJURP protects various substructures of the dimer, serving both as a folding and binding chaperone PMID: 27454815
    3. Functional p53 elicits a cell cycle arrest response, whereas, in p53-null transformed cells, the absence of arrest enables the loss of HJURP to induce severe aneuploidy and, ultimately, apoptotic cell death PMID: 28356341
    4. An increased occurrence of hepatocellular carcinoma was consistently associated with A/C or C/C genotypes of the non-synonymous SNP rs3771333 compared with the A/A genotype in both the Fusui and Haimen populations. PMID: 26863619
    5. s propose that this centromere expansion activity reflects the functional properties of HJURP, which uses this activity to contribute to the plastic establishment of a centromeric chromatin structure. PMID: 26063729
    6. 3 biomarkers in 44 patients with in situ breast cancers were evaluated: TG2 (transglutaminase 2), HJURP (Holliday junction recognition protein), and HIF-1alpha (hypoxia inducible factor-1 alpha). PMID: 25243117
    7. On the basis of our findings, we propose that HJURP serves a dual chaperone function in coordinating CenH3(CENP-A) and CENP-C recruitment. PMID: 25843710
    8. HJURP can discriminate favorable and unfavorable outcome within the luminal A subtype, outperforming the currently utilized proliferation marker Ki67, as an independent prognostic marker for luminal A patients. PMID: 25497280
    9. Phosphorylation state of HJURP controls its centromeric recruitment. HJURP binding to DNA promotes loading of CenH3CENP-A at centromeres. PMID: 25001279
    10. The study describes a novel function for human centromeric long non-coding RNAs in the recruitment of HJURP and CENP-A, implicating RNA-based chaperone targeting in histone variant assembly. PMID: 25117489
    11. The levels of the EDNRB, HJURP and p60/CAF-1 proteins were strongly associated with overall survival in high-grade gliomas patients (p<0.001, p<0.001 and p=0.002, respectively), whereas the one of PDLI4 was not (P=0.11). PMID: 24039914
    12. Mis18beta binds with and specifies the centromere localization of HJURP. PMID: 24519934
    13. HJURP has an important role in the maintenance of extremely proliferative cells of high-grade gliomas PMID: 23638004
    14. a mechanism whereby the CENP-A pre-nucleosomal complex achieves assembly of the octameric CENP-A nucleosome through the dimerization of the CENP-A chaperone HJURP. PMID: 23771058
    15. Downregulation of HJURP in young cells led to premature senescence. p53 knockdown, but not p16 knockdown, abolished senescence phenotypes caused by HJURP reduction. PMID: 23292286
    16. And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres. PMID: 23184928
    17. stringent regulation of HJURP and SCM3 expression are critical for genome stability. PMID: 21980305
    18. An amino-terminal fragment of HJURP was able to assemble CENP-A nucleosomes in vitro, demonstrating that HJURP is a chromatin assembly factor. PMID: 21768289
    19. The crystal structure of an HJURP-CENP-A-histone H4 complex shows that HJURP binds a CENP-A-H4 heterodimer PMID: 21478274
    20. Data show that HJURP mRNA level is a prognostic factor for disease-free and overall survival in patients with breast cancer and is a predictive biomarker for sensitivity to radiotherapy. PMID: 20211017
    21. found that HJURP, a member of the complex, was required for cell cycle specific targeting of CENP-A to centromeres. PMID: 20080577
    22. HJURP is a possible cell-cycle-regulated CENP-A-specific histone chaperone required for centromeric chromatin assembly PMID: 19410544
    23. HJURP is a key factor for CENP-A deposition and maintenance at centromeres PMID: 19410545
    24. hFLEG1 is associated with the CENP-A centromeric nucleosome PMID: 16622419

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  • 亚细胞定位：
    Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
  • 组织特异性：
    According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bon
  • 数据库链接：

    HGNC: 25444

    OMIM: 612667

    KEGG: hsa:55355

    STRING: 9606.ENSP00000414109

    UniGene: Hs.532968