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HINFP Antibody

  • 货号：
    CSB-PA010361GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BQA5
  • 基因名：
    HINFP
  • 别名：
    DKFZp434F162 antibody; HiNF-P antibody; HINFP antibody; HINFP_HUMAN antibody; Histone H4 gene specific protein HiNF P antibody; Histone H4 transcription factor antibody; Histone nuclear factor P antibody; MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein antibody; MBD2 interacting zinc finger 1 antibody; MBD2 interacting zinc finger protein antibody; MBD2-interacting zinc finger protein antibody; Methyl CpG binding protein 2 interacting zinc finger protein antibody; Methyl-CpG-binding protein 2-interacting zinc finger protein antibody; MIZF antibody; ZNF743 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human HINFP
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.
  • 基因功能参考文献：
    1. purified and functionally characterized the critical transcription factor HiNF-P, which is required for E2F-independent activation of the histone H4 multigene family PMID: 14585971
    2. These results suggest that transcriptional repression of Rb by MIZF could be one of the critical determinants in myogenic differentiation. PMID: 15541338
    3. HiNF-P interacts directly with p220(NPAT) to coactivate histone genes during S phase. PMID: 15988025
    4. the transcriptional silencing of the 14-3-3sigma gene is caused by promoter CpG island methylation associated with MBD2, which may play an important role in prostate cancer progression during the invasive and metastatic stages of the disease PMID: 16786000
    5. These results suggest that RFP is a mediator connecting several MBD proteins and allowing the formation of a more potent transcriptional repressor complex. PMID: 17049487
    6. HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. PMID: 17163457
    7. HiNF-P-dependent stabilization of p220NPAT reinforces signaling through the cyclin E/CDK2/p220NPAT pathway and contributes to coordinate control of histone gene expression. PMID: 17176114
    8. HiNF-P/P220NPAT regulates expression of nonhistone targets that influence competency for cell cycle progression. PMID: 17974976
    9. a novel HiNF-P-specific conserved region represents a DNA-binding determinant that plays a role in mediating histone gene expression during the cell cycle and defines HiNF-P as a cell cycle regulatory member of the zinc finger transcription factor family PMID: 18850719
    10. Results suggest that cyclin-dependent kinase inhibitors selectively control stimulation of the histone H4 gene promoter by the p220(NPAT)/HiNF-P complex. PMID: 19170105

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  • 亚细胞定位：
    Nucleus. Note=Associated with discrete nuclear foci.
  • 组织特异性：
    Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.
  • 数据库链接：

    HGNC: 17850

    OMIM: 607099

    KEGG: hsa:25988

    STRING: 9606.ENSP00000318085

    UniGene: Hs.504091