HHEX Antibody

1. HHEX is expressed in multiple types of acute myeloid leukemia (AML), with the highest levels seen in t(8;21) AML. PMID: 29263042
2. The SNPs in TCF7L2 and HHEX were genotyped by polymerase chain reaction-restriction fragment length polymorphism. There were no significant differences in the distribution of genotypes and alleles between polycystic ovary syndrome cases and controls PMID: 26563606
3. Two differentiation-related genes, HHEX and HLX, are promoters of early phase reprogramming toward pluripotency. PMID: 27335261
4. This finding highlights the potentially functional alteration with HHEX rs1111875 and rs7923837 polymorphisms may increase colorectal cancer susceptibility. PMID: 27105501
5. The aim of this study was to examine the association between HHEX (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .The HHEX gene rs5015480 C allele may be a risk allele of GDM that is associated with increased BMI during pregnancy PMID: 27684496
6. Vascular smooth muscle protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism. PMID: 28927755
7. HHEX over expression induced by human cytomegalovirus infection closely associated with vascular proliferative diseases. PMID: 27965937
8. The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX. PMID: 27377502
9. These studies identify uPA-dependent de-repression of vegfr1 and vegfr2 gene transcription through binding to HHEX/PRH as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF and identifies a potential new target for control of pathologic angiogenesis. PMID: 27151212
10. Low HHEX mutation is associated with Thyroid Dysgenesis. PMID: 26757609
11. Data suggest that hematopoietically expressed homeobox protein (HHEX) downmodulation by promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein (PML-RARalpha) is a key event during acute promyelocytic leukemia (APL) pathogenesis. PMID: 27052408
12. Hhex binds to the Cdkn2a locus and directly interacts with the Polycomb-repressive complex 2 (PRC2) to enable H3K27me3-mediated epigenetic repression PMID: 26728554
13. Data suggest that Hhex is a novel regulator of c-Myc function that limits c-Myc activity in transformed cells. PMID: 25220416
14. PRH controls the migration of multiple epithelial cell lineages in part at least through the direct transcriptional regulation of Endoglin PMID: 24240683
15. HHEX promotes hepatic specification by repressing EOMES expression. PMID: 24651531
16. Data indicate the potential importance of CDKAL1 protein and homeobox protein HHEX in glucose homeostasis in this Alaska Native population with a low prevalence of type 2 diabetes (T2D). PMID: 24112421
17. In all the CHD patients, we did not find any causative mutations in the coding region of the HHEX gene. PMID: 23929257
18. Tissue-specific knockdown of the HHEX ortholog dHHEX (CG7056) directed metabolic defects and enhanced lethality; for example, fat-body-specific loss of dHHEX led to increased hemolymph glucose and reduced insulin sensitivity PMID: 23445342
19. In conclusion, this epistatic interaction showed a high degree of consistency when stratifying by sex, the epsilon4 allele of apolipoprotein E genotype, and geographic region. PMID: 23036584
20. Data indicate associations of SNPs in eight loci CXCR4, HHEX, FOXA2, NGN3, TCF7L2, FLJ39370 (C4orf32), LOC646279 (RPL21P7) and THADA with body mass index (BMI) and weight. PMID: 23349771
21. A significant association of rs1111875, rs5015480 and rs7923837 in HHEX gene with type 2 diabetes. PMID: 23166797
22. Association to type 2 diabetes was found for rs13266634 (SLC30A8), rs7923837 (HHEX), rs10811661 (CDKN2A/2B), rs4402960 (IGF2BP2), rs12779790 (CDC123/CAMK1D), and rs2237892 (KCNQ1). PMID: 22923468
23. None of the 12 SNPs in the six genes (KCNJ11, TCF7L2, SLC30A8, HHEX, FTO and CDKAL1) uncovered in the genome-wide association studies were associated with polycystic ovary syndrome. PMID: 22443257
24. re-establishment of gene control by PRH is in part responsible for the therapeutic effects of dasatinib. PMID: 22874537
25. Genetic variants of the IDE-KIF11-HHEX region at 10q23.33 contribute to type 2 diabetes susceptibility. PMID: 22506066
26. Loss of HHEX is associated with colorectal cancer. PMID: 21656028
27. The proline rich homeodomain protein PRH/Hhex forms predominantly octameric and/or hexadecameric species in solution as well as larger assemblies. PMID: 22540015
28. The associations between SNPs of TCF7L2, CDKAL1, SLC30A8 and HHEX and the development of DR and DN. PMID: 22487833
29. HHEX, is more likely to represent the genuine signals of T2DM in the Tunisian population. PMID: 21510814
30. Single nucleotide polymorphism (SNP) analysis revealed that the sequence variant (rs5015480) near HHEX and two SNPs (rs7756992 and rs9465871) in CDKAL1 were associated with the susceptibility of type 2 diabetes mellitus in females, but not in males. PMID: 21368910
31. HHEX, IDE and SLC30A8 showed strongest tissue-specific mRNA expression bias and are associated with increased risk of type 2 diabete. PMID: 20703447
32. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20879858
33. Our data indicate that common genetic variants in two genes previously related to obesity (FTO) and diabetes (HHEX) by genome-wide association scans were not associated with endometrial cancer risk. PMID: 20647405
34. Data report a novel association between the fetal ADCY5 type 2 diabetes risk allele and decreased birthweight, and confirm in meta-analyses associations between decreased birthweight and the type 2 diabetes risk alleles of HHEX-IDE and CDKAL1. PMID: 20490451
35. Type 2 diabetes susceptibility alleles at HHEX are associated with low body mass index at 8 years in children who were born large for gestational age. PMID: 20460429
36. There was no association of the genetic polymorhism rs1111875 of HHEX with the occurrence of polycystic ovary syndrome in the Chinese population. PMID: 20041287
37. PRH is a key regulator of the VEGF signaling pathway and describe a mechanism whereby PRH plays an important role in tumorigenesis and leukemogenesis. PMID: 20176809
38. the same genetic HHEX-IDE variant, which is associated with type 2 diabetes from previous studies, also influences pediatric body mass index PMID: 19933996
39. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) PMID: 20075150
40. the interaction between Hhex and SOX13 may contribute to control Wnt/TCF1 signaling in the early embryo. PMID: 20028982
41. there is an association between PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 and type 2 diabetes in the Chinese population PMID: 19862325
42. HHEX has been implicated in pancreas development and the regulation of insulin secretion and risk of type 2 diabetes. PMID: 20080751
43. genomic organization and chromosome 10 mapping PMID: 11701950
44. PRH is a negative regulator of eIF4E in myeloid cells, interacting with eIF4E through a conserved binding site typically found in translational regulators PMID: 12554669
45. HEX may not affect the differentiation of endothelial cells but acts as a negative regulator of angiogenesis. PMID: 12588764
46. PRH interacts with the HC8 subunit of the proteasome in the context of both 20 and 26 S proteasomes and is associated with the proteasome in K562 hematopoietic cells; the proline-rich PRH N-terminal domain is responsible for this interaction. PMID: 12826010
47. Hex can act as a T lineage oncogene when misexpressed in hematopoietic precursor cells PMID: 14555989
48. Tgf-beta mediated repression of flk-1/KDR and mediated repression of flk-1/KDR and VEGF signaling involves the inducible formation of inhibitory Hex-GATA signaling Hex-GATA involves the formation of Hex-GATA complexes. PMID: 15016828
49. Pax8 regulates the transcriptional activity of Hex promoter; several Pax8 binding sites in the Hex promoter are present PMID: 15062550
50. Hex, a hematopoietically expressed homeobox protein, induces transcription of the SM22alpha gene by facilitating the interaction between SRF and its cognate binding site in embryonic fibroblasts. PMID: 15242862

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HGNC: 4901

OMIM: 604420

KEGG: hsa:3087

STRING: 9606.ENSP00000282728

UniGene: Hs.118651