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  4. HEY2 Antibody

HEY2 Antibody

  • 货号：
    CSB-PA008379
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBP5
  • 基因名：
    HEY2
  • 别名：
    bHLHb32 antibody; Cardiovascular helix loop helix factor 1 antibody; Cardiovascular helix-loop-helix factor 1 antibody; CHF1 antibody; Class B basic helix-loop-helix protein 32 antibody; GRIDLOCK antibody; GRL antibody; Hairy and enhancer of split related 2 antibody; Hairy and enhancer of split-related protein 2 antibody; Hairy related transcription factor 2 antibody; Hairy-related transcription factor 2 antibody; Hairy/enhancer-of-split related with YRPW motif protein 2 antibody; hCHF1 antibody; HERP antibody; HERP1 antibody; HES related repressor protein 1 antibody; HES-related repressor protein 2 antibody; HESR-2 antibody; HESR2 antibody; hey2 antibody; HEY2_HUMAN antibody; hHRT2 antibody; HRT-2 antibody; HRT2 antibody; MGC10720 antibody; Protein gridlock homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human HRT2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
  • 基因功能参考文献：
    1. The findings identify HEY2 as a novel component of the NKX2-5 cardiac transcriptional network. PMID: 29636455
    2. HEY2 as a promising biomarker for unfavorable outcomes and a novel therapeutic target for the clinical management of HCC PMID: 27191260
    3. Genetic variation of HEY2 is associated with Brugada syndrome through alteration of ion channel expression in the cardiac ventricular wall. PMID: 28637782
    4. Individuals with HEY2 duplications should be screened for congenital heart defects. PMID: 25832314
    5. HEY2 CC genotype may be a favorable prognostic marker for BrS, protectively acting to prevent ventricular fibrillation presumably by regulating the repolarization current. PMID: 26729854
    6. Data indicate that culture abrogated differential gene expression in part due to gradual loss of canonical Notch activity and HEY2 expression. PMID: 24108462
    7. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death PMID: 23872634
    8. Hey2 and COUP-TFII have an important role in arteriovenous differentiation of human endothelial cells. PMID: 23744056
    9. Report down-regulation of Notch signaling components NOTCH3 and HEY2 in abdominal aortic aneurysms. PMID: 22310065
    10. Through activating the Dll4-Notch-Hey2 signaling pathway, HGF indirectly promotes the proliferation and migration ability of cells, so that offspring artery branches are formed. PMID: 21362320
    11. To clarify the role of HEY2 in human CHD and AGS, we screened by direct sequencing 23 children with CHD and 38 patients diagnosed with AGS. Mutation of HEY2 is not a major contributing factor. PMID: 15389319
    12. HERP1 may play a role in promoting the phenotypic modulation of vascular smooth muscle cells during vascular injury and atherosclerotic process by interfering with SRF binding to CArG-box PMID: 16151017
    13. CHF1/Hey2 may affect smooth-muscle cell phenotype through an important transcriptional mechanism PMID: 16293227
    14. This result suggests a possible role of HEY2 in the regulation of ventricular septation in humans. PMID: 16329098
    15. The absence of mutations in NOTCH2 and Hey2 its downstream target in the heart does not exclude the possibility that other genes in this pathway might be implicated in the diverse phenotypes observed in Alagille syndrome PMID: 18266235

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HEY family
  • 数据库链接：

    HGNC: 4881

    OMIM: 604674

    KEGG: hsa:23493

    STRING: 9606.ENSP00000357348

    UniGene: Hs.144287