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HECTD3 Antibody

  • 货号：
    CSB-PA010275GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q5T447
  • 基因名：
    HECTD3
  • 别名：
    E3 ubiquitin-protein ligase HECTD3 antibody; HECD3_HUMAN antibody; HECT antibody; HECT domain containing protein 3 antibody; HECT domain-containing protein 3 antibody; HECTD3 antibody; Probable E3 ubiquitin protein ligase HECTD3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human HECTD3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8.
  • 基因功能参考文献：
    1. HECTD3 as a tumor suppressor modulating the activity of this important oncogenic signaling pathway. PMID: 28636940
    2. Overexpression of MALT1 partially rescues HECTD3 depletion-induced apoptosis. PMID: 23358872
    3. All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara. PMID: 18194665
  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 数据库链接：

    HGNC: 26117

    KEGG: hsa:79654

    STRING: 9606.ENSP00000361245

    UniGene: Hs.525084