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HCRTR2 Antibody

  • 货号：
    CSB-PA949345
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse kidney tissue, Mouse brain tissue, Mouse heart tissue, Primary antibody: CSB-PA949345(HCRTR2 Antibody) at dilution 1/1100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds
  • 其他：

产品详情

  • Uniprot No.：
    O43614
  • 基因名：
  • 别名：
    Hcr tr2 antibody; Hcrt receptor 2 antibody; Hcrtr2 antibody; Hypocretin (orexin) receptor 2 antibody; Hypocretin receptor 2 antibody; Hypocretin receptor type 2 antibody; Orexin 2 receptor antibody; Orexin A/Orexin B receptor antibody; Orexin receptor 2 antibody; Orexin receptor type 2 antibody; Orexin type 2 receptor antibody; Ox-2-R antibody; Ox2-R antibody; Ox2r antibody; OX2R_HUMAN antibody; Type 2 hypocretin receptor antibody; Type 2 orexin receptor antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human HCRTR2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
  • 基因功能参考文献：
    1. The rs2653349 (G1246A) polymorphism of the HCRTR2 gene reduces the chance of developing cluster headache. PMID: 29959630
    2. Association between HCRTR2, ADH4,CLOCK gene polymorphisms and cluster headache was not significant in the present study. PMID: 29318394
    3. The present study demonstrated that aa residues in the C-terminus serve an important role in the expression and signal transduction of OX2R. In addition, the aa residues in different locations possess evidentially different roles. PMID: 28487995
    4. This study showed that Lack of Association between Genetic Polymorphism of ox2r gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population PMID: 27335043
    5. G-protein-dependency of OX2 receptor signalling PMID: 27237973
    6. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the HCRTR2 gene. PMID: 26555080
    7. The study determined structures of OX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution and explored mechanisms of antagonist the subtype selectivity between OX1R and OX2R. PMID: 26950369
    8. our meta-analysis provides genetic evidence for a role of HCRTR2 in cluster headache PMID: 25398231
    9. Heart failure patients with minor allele for rs7767652, upstream of hypocretin (orexin) receptor-2 (HCRTR2), were less likely to have improved left ventricular function and a lower prevalence of ejection fraction >35% PMID: 26653627
    10. the nonsynonymous rs2653349 single nucleotide polymorphism (SNP) (located on the gene that encodes orexin [hypocretin] receptor 2) was selected as the most notable SNP associated with Fagerstrom Test for Nicotine Dependence. PMID: 26289589
    11. Antibodies from vaccine-associated narcolepsy sera cross-reacted with both influenza nucleoprotein and hypocretin receptor 2. PMID: 26136476
    12. The genotypic and allelic frequencies of the rs2653349 polymorphism were different between Alzheimer's disease patients and controls. The carriage of the G allele was associated with an increased AD risk. PMID: 24969517
    13. using lipid-mediated crystallization and protein engineering with a novel fusion chimaera, the structure of the human OX2R bound to suvorexant at 2.5 A resolution is solved PMID: 25533960
    14. DQ B1 but not HLA-DR typing, TNF-alpha levers, HCRTR1 and HCRTR2 were higher in narcolepsy-cataplexy/schizophrenia patients. PMID: 24268496
    15. Orexinergic innervation and expression of genes encoding OX2R receptor are upregulated in transgenic mice at dusk. PMID: 24599460
    16. Expression of the OX2R protein was detected in normal endometrial epithelia, whereas it was frequently lacking in endometrial endometrioid carcinoma. PMID: 23482607
    17. Data demonstrated that hOX2R expression is regulated by a complex involving a proximal PKA/PKC-regulated promoter and a distal promoter regulating tissue-specific expression of alternative transcripts which in turn regulate receptor levels. PMID: 20156195
    18. The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache. PMID: 15477554
    19. All adrenal cortex adenomas expressed OX1-R and OX2-R mRNAs, and real-time PCR showed that the expression of both receptors was up-regulated in adenomas PMID: 15797953
    20. Our results do not support a role of the HCRTR2 G1246A polymorphism in drug responses in CH. PMID: 17376114
    21. polymorphism of the HCRTR2 gene may modulate the genetic risk for cluster headache PMID: 17563843
    22. the HCRTR2 gene is not a genetic risk factor in migraine. PMID: 17645762
    23. This study does not support a major contribution of the HCRTR2 G1246A polymorphism to the pathogenesis of migraine in contrast to its effects in cluster headache. PMID: 17883525
    24. Three new polymorphisms of the HCRTR2 gene are significantly associated with cluster headache. PMID: 18399985
    25. This study describes the intracellular signalling pathways involved in OX2R-mediated ERK(1/2) and p38 MAPK activation. PMID: 18599270
    26. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. PMID: 19751316

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    HGNC: 4849

    OMIM: 602393

    KEGG: hsa:3062

    STRING: 9606.ENSP00000359899

    UniGene: Hs.151624