HCFC1 Antibody

1. Data show that Myc boxes (MbIV) is required for the association of MYC with the abundant transcriptional coregulator host cell factor-1 (HCF-1). PMID: 26522729
2. The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis-element, which engages a THAP11/HCF-1 complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros and NFKB1 PMID: 27576892
3. Beyond its well-known role in adding beta-O-GlcNAc to serine and threonine residues of nuclear and cytoplasmic proteins, OGT also acts as a protease in the maturation of the cell cycle regulator, HCF-1, and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review) PMID: 27294441
4. findings show that cellular factors OCT2 and HCF1 bind OriP in association with Epstein-Barr virus nuclear antigen 1 to maintain elevated histone H3K4me3 and transcriptional enhancer function PMID: 27009953
5. O-GlcNAcylation of the transcription regulators Host Cell Factor-1 (HCF-1) and Ten-Eleven Translocation protein 2 (TET2) could be readily observed. Our study raises questions on the occurrence and abundance of O-GlcNAcylation as a histone modification PMID: 26075789
6. These results demonstrate that distinct OGT-binding sites in HCF-1 promote proteolysis, and provide novel insights into the mechanism of this unusual protease activity. PMID: 26305326
7. our work identifies plausible cellular consequences of missense HCFC1 variants and identifies likely and relevant disease mechanisms that converge on embryonic stages of brain development. PMID: 25740848
8. We report here two brothers with dysmorphic features and complex malformations resulting from an X-linked inherited cobalamin deficiency due to HCFC1 gene mutation. PMID: 25595573
9. THAP11, ZNF143, and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F occupancy. PMID: 25437553
10. study reports the tetratricopeptide-repeat domain of O-GlcNAc transferase binds the carboxyl-terminal portion of an HCF-1 proteolytic repeat such that the cleavage region lies in the glycosyltransferase active site above uridine diphosphate-GlcNAc; protein glycosylation and HCF-1 cleavage occur in the same active site PMID: 24311690
11. A missense mutation in a global transcriptional coregulator, HCFC1, was identified as the genetic basis of an X-linked form of combined methylmalonic acidemia and hyperhomocysteinemia. PMID: 24011988
12. HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy. PMID: 23539139
13. MLL5 can associate with HCF-1 and then be recruited to E2F1-responsive promoters to stimulate H3K4 trimethylation and transcriptional activation. PMID: 23629655
14. A noncoding, regulatory mutation was identified in the binding site of transcription factor YY1 in the HCFC1 gene in patients with nonsyndromic intellectual disability. PMID: 23000143
15. Host cell factor C1 recruits O-GlcNAc transferase to O-GlcNAcylate PGC-1alpha, and O-GlcNAcylation facilitates the binding of the deubiquitinase BAP1, thus protecting PGC-1alpha from degradation and promoting gluconeogenesis. PMID: 22883232
16. HCF-1(N)-HCF-1(C) association via an integrated Fn3 structure permits an NLS to facilitate formation of a transcriptional regulatory complex PMID: 23045687
17. THAP11 was found to associate physically with the transcriptional coregulator HCF-1 (host cell factor 1) and recruit HCF-1 to target promoters PMID: 22371484
18. Studies suggest that BAP1 influences cell proliferation at G1/S by co-regulating transcription from HCF-1/E2F-governed promoters. PMID: 21484256
19. These results reveal an unexpected role of OGT in HCF-1 proteolytic maturation and an unforeseen nexus between OGT-directed O-GlcNAcylation and proteolytic maturation in HCF-1 cell-cycle regulation. PMID: 21295698
20. HCF-1 interacts with the middle region of YY1 encompassing the glycine-lysine-rich domain and is essential for the formation of a ternary complex with YY1 and BAP1 in vivo. PMID: 20805357
21. Data show that the HCF-1 Basic region displays striking structural flexibility for controlling cell proliferation. PMID: 20126307
22. THAP1 mediates the recruitment of HCF-1 to the RRM1 promoter during endothelial cell proliferation and that HCF-1 is essential for transcriptional activation of RRM1. PMID: 20200153
23. NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes. PMID: 20018852
24. Data show that Asf1b localizes with HCF-1 in viral replication foci and depletion of Asf1b results in significantly reduced viral DNA accumulation. PMID: 20133788
25. HCF-1 activity is regulated by HPIP by modulating its subcellular localization PMID: 12235138
26. HCF-1 contains an activation domain (HCF-1(AD)) required for maximal transactivation by VP16 and its cellular counterpart LZIP. PMID: 12271126
27. The results presented in this paper suggest that HCF-1 can broadly regulate transcription, both positively and negatively, through selective modulation of chromatin structure. PMID: 12670868
28. These results suggest that host cell factor-1 (HCF-1) links the regulation of exit from mitosis and the G(1) phase of cell growth, possibly to coordinate the reactivation of gene expression after mitosis. PMID: 12743030
29. Three proteins found to contain the HCF-binding motif were further analyzed for their ability to use HCF-1 as a coactivator. Krox20 and E2F4 showed a strong requirement for HCF-1 to activate activation transcription, while estrogen receptor-alpha did not. PMID: 14532282
30. The fibronectin domain of HCF interacts with HCF in the herpes simplex virus VP16-induced transcriptional activating complex, an association requiring a region outside the putative HCF beta-propeller fold PMID: 16042417
31. HCF-1 was required for recruitment of the histone methyltransferases Set1 and MLL1, leading to histone H3K4 trimethylation and transcriptional activation. PMID: 17578910
32. During the G1-to-S phase transition, HCF-1 recruits the mixed-lineage leukemia (MLL) and Set-1 histone H3 lysine 4 methyltransferases to E2F-responsive promoters and induces histone methylation and transcriptional activation. PMID: 17612494
33. The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1. PMID: 18343819
34. A viable hypothesis for disease development is presented based on the known interaction between HCFC1 and the herpes simplex viral protein VP16 PMID: 18520591
35. The identified components revealed factors involved in histone methylation and cell cycle control and include Ash2L, RbBP5, WDR5, HCF-1, DBC-1, and EMSY. PMID: 19131338
36. The most interesting biological findings were the binding sites for SREBP-1 in genes for host cell factor C1 (HCFC1), involved in cell cycle regulation PMID: 19292868
37. Sequence changes in the E2F1 HCF-1-binding site can modulate both up and down the ability of E2F1 to induce apoptosis indicating that HCF-1 association with E2F1 is a regulator of E2F1-induced apoptosis. PMID: 19763085
38. BAP1 regulates cell proliferation by deubiquitinating HCF-1 PMID: 19815555

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HGNC: 4839

OMIM: 300019

KEGG: hsa:3054

STRING: 9606.ENSP00000309555

UniGene: Hs.83634