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Gabra3 Antibody

  • 货号：
    CSB-PA593781
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extract from rat brain and mouse brain tissue and C6 cells using GABA A Receptor a3 Antibody
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Gabra3 Polyclonal antibody
  • Uniprot No.：
    P20236
  • 基因名：
    Gabra3
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat,Mouse
  • 免疫原：
    Peptide sequence around aa. 33~37(R-R-Q-E-P)derived from Rat GABA A Receptor a3.
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
  • 基因功能参考文献：
    1. Sp4 functionally regulates the transcription of Gabra1 (GABAA alpha1) and Gabra2 (GABAA alpha2), but not Gabra3 (GABAA alpha3) subunit genes. PMID: 26469128
    2. presence of alpha2 and alpha3 subunits during early development might make them more amenable to becoming sensitized by environmental stressors, whereas the relative paucity of alpha1 subunits at this age might limit the sensitization of this subunit. PMID: 22044189
    3. clustering of GABA(A)R alpha2, alpha3, and GlyRs by gephyrin is mediated by distinct mechanisms at mixed glycinergic/GABAergic synapses. PMID: 21880742
    4. Results describe the differential cellular distribution of alpha1, alpha2 and alpha3 GABA(A) receptor subunits in relation to striatopallidal (Str-GP) and pallidopallidal (GP-GP) synapses. PMID: 21219474
    5. Distinct alpha subunit contributions create heterogeneity in developmental acceleration of IPSC decay in neocortex. PMID: 12433958
    6. Developmental trends of subunits alpha1 and alpha3 intersected at P12. Switch in alpha3 and alpha1 during development may mediate different functional properties of GABA transmission. PMID: 14729731
    7. a domain of four amino acids within the subunit mediates the distinct sensitivities to GABA;identified motifs contribute to a structure involved in the transduction of the binding signal rather than to the binding itself PMID: 15199051
    8. These data demonstrate that the modulation of breathing via GABA(A) receptor activation will be determined by the overall balance of negative and positive neurosteroid modulators within respiratory nuclei. PMID: 16690709
    9. Presence of persistent GABA(A)-mediated inhibitory modality in presympathetic paraventricular nucleus neurons, which plays major role in modulating their excitability and firing activity. PMID: 17495040
    10. localized changes in GABA(A)R expression acting at highly specific points in the interconnected thalamocortical network lie at the heart of idiopathic generalized epilepsy PMID: 17630284
    11. Our findings suggest that various combinations of GABA(A) alpha3-, theta- and epsilon-subunits may be assembled at a regional and developmental level in the brain. PMID: 19249336

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA3 sub-subfamily
  • 组织特异性：
    Expressed in most brain regions.
  • 数据库链接：

    STRING: 10116.ENSRNOP00000050712

    UniGene: Rn.10367