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GZMH Antibody

  • 货号：
    CSB-PA966723
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from K562 cells, using GRAH antibody.
    • Immunofluorescence analysis of A549 cells, using GRAH antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GZMH Polyclonal antibody
  • Uniprot No.：
    P20718
  • 基因名：
    GZMH
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human GRAH.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.
  • 基因功能参考文献：
    1. Granzyme H did directly process DFF45, potentially leading to DNA damage. PMID: 23352961
    2. Upon reactive center loop cleavage at Phe-343,SERPINB1 covalently complexes with GzmH. SERPINB1 overexpression suppresses GzmH- or LAK cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH for the suicide inhibition. PMID: 23269243
    3. An unusual RKR motif (Arg39-Lys40-Arg41), conserved only in GzmH, helps define the S3' and S4' binding regions, indicating the preference for acidic residues at the P3' and P4' sites. PMID: 22156497
    4. GzmH suppresses viral replication through association with the hepatitis B virus x protein. PMID: 22156339
    5. Granzyme C rapidly induces target cell death by attacking nuclear and mitochondrial targets and that these targets are distinct from those used by granzyme B to cause classical apoptosis. PMID: 12515723
    6. granzyme H complements the pro-apoptotic function of granzyme B in human NK cells PMID: 15069086
    7. Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition. PMID: 17363894
    8. Expression levels of GzmH in naive natural killer cells and its killing ability support the role of the protease in triggering an alternative cell-death pathway in innate immunity. PMID: 17409270
    9. GzmH may play an essential role in caspase-dependent pathogen clearance in the innate immunity that may complement the proapoptotic function of GzmB in human NK cells. PMID: 17765974
    10. Granzyme H could have evolved a proteolytic specificity that both interferes directly with adenovirus replication and prevents the virus from blocking the potent pro-apoptotic activity of granzyme B. PMID: 17766182
    11. Cleavage of La protein by granzyme H generates a COOH-terminal truncated form of La protein that loses nuclear localization and decreases hepatitis C virus-internal ribosome entry site-mediated translational activity. PMID: 19039329

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  • 亚细胞定位：
    Cytolytic granule.
  • 蛋白家族：
    Peptidase S1 family, Granzyme subfamily
  • 组织特异性：
    Constitutively expressed in NK cells.
  • 数据库链接：

    HGNC: 4710

    OMIM: 116831

    KEGG: hsa:2999

    STRING: 9606.ENSP00000216338

    UniGene: Hs.348264