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GUCY1A3 Antibody

  • 货号：
    CSB-PA002669
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of NIH-3T3 cells using GCS-α-1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q02108
  • 基因名：
  • 别名：
    GC S alpha 1 antibody; GC SA3 antibody; GCS alpha 1 antibody; GCS alpha 3 antibody; GCS-alpha-1 antibody; GCS-alpha-3 antibody; GCYA3_HUMAN antibody; Guanylate cyclase 1 soluble alpha 3 antibody; Guanylate cyclase soluble subunit alpha 1 antibody; Guanylate cyclase soluble subunit alpha 3 antibody; Guanylate cyclase soluble subunit alpha-3 antibody; Guanylate cyclase; nitric oxide-sensitive; alpha-1 subunit antibody; Guc1a1 antibody; GUC1A3 antibody; GUCA3 antibody; GUCSA3 antibody; Gucy1a1 antibody; Gucy1a3 antibody; MYMY6 antibody; nitric oxide-sensitive Guanylate cyclase; alpha-1 subunit antibody; NOGC; alpha-1 subunit antibody; Soluble guanylate cyclase large subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GCS-α-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Human Red Blood Cells carry catalytically active alpha1beta1-soluble guanylate cyclase (isoform 1). Red cell soluble guanylate cyclase activity is fully preserved in patients with stable coronary artery disease. PMID: 29024896
    2. Peptide B-8R killed both androgen-dependent and androgen-independent prostate cancer cells that expressed sGCalpha1, but not cells that do not express this gene. Peptide B-8R induced apoptosis of prostate cancer cells. PMID: 28859127
    3. In conclusion, rare coding variants in GUCY1A3 lead to reduced cGMP formation which can be rescued by a soluble guanylyl cyclase stimulator in vitro PMID: 27342234
    4. Rs7692387 is located in an intronic site that modulates GUCY1A3 promoter activity. The transcription factor ZEB1 binds preferentially to the nonrisk allele, leading to an increase in GUCY1A3 expression, higher sGC levels, and higher sGC activity after stimulation. PMID: 28487391
    5. Mutations in the GUCY1A3 gene are associated with moyamoya disease, achalasia, and hypertension. PMID: 26777256
    6. Expression of the alpha1-A680T sGC variant in reporter cells resulted in higher cyclic guanosine monophosphate production compared with the wild-type enzyme and the purified alpha1-A680T sGC exhibited enhanced sensitivity to nitric oxide in vitro. PMID: 25373139
    7. Dynamic interplay between hsp90, apo-sGC-beta1, and sGC-alpha1 in response to NO is unprecedented and represent new steps by which cells can modulate the heme content and activity of sGC for signaling cascades. PMID: 24733395
    8. ZNF280B upregulates GUCY1A3 expression and downregulates TP53 in prostate cancer cells. PMID: 24236047
    9. homozygous mutations in GUCY1A3, which encodes the alpha1 subunit of soluble guanylate cyclase, the major receptor for nitric oxide, might play a role in moyamoya and achalasia PMID: 24581742
    10. The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase PMID: 22690686
    11. GCS-alpha-1 regulation of p53 activity is important in prostate cancer biology and may represent an important mechanism of p53 down-regulation. PMID: 22174378
    12. We concluded that the alpha-subunit and the beta(1)(191-619) domain exert structural strains on the heme domain. PMID: 22223482
    13. analysis of pharmacological response to direct sGC activators in coronary artery disease patients PMID: 21794866
    14. A novel insight into the heme and NO/CO binding mechanism of the alpha subunit of human soluble guanylate cyclase PMID: 21725643
    15. C-alpha1 sGC splice form is expressed at high levels in differentiating cells and its intracellular distribution varies from canonical alpha1 sGC subunit. PMID: 20964618
    16. NO, depending on its concentration, may act in human PBMCs as a stimulator of IL-6 expression and modulator of NF-KB involving the sGC/cGMP/PKG pathway PMID: 21414799
    17. Soluble guanylate cyclases could be the target molecules for controlling neo-vascularization in a subset of human malignant gliomas. PMID: 15201957
    18. guanylate cyclase has a role in pulmonary arterial hypertension PMID: 18550612

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  • 相关疾病：
    Moyamoya disease 6 with achalasia (MYMY6)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 组织特异性：
    Detected in brain cortex and lung (at protein level).
  • 数据库链接：

    HGNC: 4685

    OMIM: 139396

    KEGG: hsa:2982

    STRING: 9606.ENSP00000296518

    UniGene: Hs.24258