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GTF2H5 Antibody

  • 货号：
    CSB-PA010014EA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA010014EA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA010014EA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA010014EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GTF2H5 Polyclonal antibody
  • Uniprot No.：
    Q6ZYL4
  • 基因名：
  • 别名：
    GTF2H5 antibody; C6orf175 antibody; TTDA antibody; General transcription factor IIH subunit 5 antibody; General transcription factor IIH polypeptide 5 antibody; TFB5 ortholog antibody; TFIIH basal transcription factor complex TTD-A subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human General transcription factor IIH subunit 5 protein (1-71AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GTF2H5 Antibody (CSB-PA010014EA01HU)，的标记方式是Non-conjugated。对于GTF2H5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA010014EB01HU GTF2H5 Antibody, HRP conjugated ELISA
    FITC CSB-PA010014EC01HU GTF2H5 Antibody, FITC conjugated
    Biotin CSB-PA010014ED01HU GTF2H5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.
  • 基因功能参考文献：
    1. Low levels of GTF2H5 are associated with enhanced prognosis in high-grade serous ovarian cancer patients and may contribute to cisplatin sensitization. PMID: 26463438
    2. Transcriptional differences found between various TFIIH subunit variants participate in the phenotypic variability observed among xeroderma pigmentosum, XP associated with Cockayne syndrome, and trichothiodystrophy individuals. PMID: 25620205
    3. Findings give new insights into the behavior of TTDA within the context of a living cell and thereby shed light on the complex phenotype of TTD-A patients. PMID: 23729738
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20522537
    5. p8/TTD-A, the tenth subunit of TFIIH, has a critical role in DNA repair where it triggers DNA opening by stimulating XPB ATPase activity together with the damage recognition factor XPC-hHR23B. PMID: 16427011
    6. TTDA is the first Transcription Factor IIH subunit with a primarily nucleotide excision repair-dedicated role in vivo. PMID: 16669699
    7. The solution structure of the p8/TTD-A protein, a small alpha/beta protein built around an antiparallel beta-sheet that forms a homodimer with an extended interface, is reported. PMID: 17350038
    8. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 18270339

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  • 相关疾病：
    Trichothiodystrophy 3, photosensitive (TTD3)
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    TFB5 family
  • 数据库链接：

    HGNC: 21157

    OMIM: 608780

    KEGG: hsa:404672

    STRING: 9606.ENSP00000415032

    UniGene: Hs.356224