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  4. GSTA3 Antibody

GSTA3 Antibody

  • 货号：
    CSB-PA476221
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA476221(GSTA3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA476221(GSTA3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human testis tissue, HepG2 cells, Primary antibody: CSB-PA476221(GSTA3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q16772
  • 基因名：
    GSTA3
  • 别名：
    Glutathione S alkyltransferase A3 antibody; Glutathione S aralkyltransferase A3 antibody; Glutathione S aryltransferase A3 antibody; Glutathione S transferase A3 3 antibody; Glutathione S transferase A3 antibody; glutathione S transferase A3 subunit antibody; Glutathione S transferase alpha 3 antibody; Glutathione S transferase alpha type (Ya) antibody; glutathione S transferase Yc 1 antibody; glutathione S transferase Yc1 subunit antibody; Glutathione S-transferase A3 antibody; Glutathione S-transferase A3-3 antibody; Glutathione S-transferase Ya3 antibody; Glutathione S-transferase Yc antibody; glutathione transferase A3 subunit antibody; Glutathione transferase alpha 3 antibody; GST 2 2 antibody; GST AA antibody; GST class alpha antibody; GST class alpha member 3 antibody; GST class-alpha member 3 antibody; GST Yc1 antibody; GSTA 3 antibody; GSTA3 3 antibody; Gsta3 antibody; GSTA3-3 antibody; GSTA3_HUMAN antibody; Gstyc antibody; GTA 3 antibody; GTA3 antibody; MGC22232 antibody; S (hydroxyalkyl)glutathione lyase A3 antibody; Yc1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human GSTA3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide.
  • 基因功能参考文献：
    1. GSTA3 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. Density functional theory calculations used to propose a refined mechanism for the isomerization of delta(5)-androstene-3,17-dione catalyzed by GST A3-3 PMID: 24739064
    3. analysis of how isomerization of the steroid Delta(5)-androstene-3,17-dione by the glutathione transferase A3-3 PMID: 25248748
    4. describe an I71L polymorphism in GSTA3 that occurs at a low frequency in African populations PMID: 15454730
    5. Analysis of the active centers of hGSTA3-3 reveals that residues in positions 12 and 208 may contribute to its disparate isomerase activity toward Delta(5)-AD. PMID: 15595823
    6. Significantly contributes to the double-bond isomerization necessary for steroid hormone biosynthesis in complex systems, thereby complementing the indispensable 3beta-hydroxysteroid oxidoreductase activity of 3beta-hydroxysteroid dehydrogenase. PMID: 18426392

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GST superfamily, Alpha family
  • 数据库链接：

    HGNC: 4628

    OMIM: 605449

    KEGG: hsa:2940

    STRING: 9606.ENSP00000211122

    UniGene: Hs.102484