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GSR Antibody

  • 货号：
    CSB-PA436998
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA436998(GSR Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA436998(GSR Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Jurkat cells, Hela cells, A549 cells, Primary antibody: CSB-PA436998(GSR Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P00390
  • 基因名：
  • 别名：
    GLR1 antibody; GLUR antibody; Glutathione reductase antibody; Glutathione reductase mitochondrial antibody; Glutathione reductase; mitochondrial antibody; GR antibody; Gr1 antibody; GRase antibody; GRD 1 antibody; GRD1 antibody; GSHR_HUMAN antibody; GSR antibody; MGC78522 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human GSR
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Maintains high levels of reduced glutathione in the cytosol.
  • 基因功能参考文献：
    1. It has been shown that acute aerobic exercise activates Nrf2 in young men, irrespective of training intensity, but that high-intensity exercise demonstrated a greater effect on increasing glutathione reductase activity which could indicate improved redox potential. PMID: 28693341
    2. GSR expression was higher in TMZ-resistant cells than in sensitive cells. GSR silencing in drug-resistant cells improved the sensitivity of cells to TMZ or cisplatin. Over-expression resulted in resistance. GSR partially prevented the oxidative stress caused by L-buthionine -sulfoximine. The action of GSR in drug resistance is associated with the modulation of redox homeostasis. High GSR correlated with lower survival. PMID: 29105080
    3. Plasma glutathione reductase (GR) activity was correlated with erythrocyte GR activity and the erythrocyte reduced glutathione/glutathione disulfide ratio. A decrease in plasma GR activity was associated with an increase in mortality in septic shock. PMID: 26316444
    4. Glutathione reductase reduces mitochondrial protein mitoNEET [2Fe-2S] clusters. PMID: 25645953
    5. The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR and AA rs3763511of gene DKK4. PMID: 26419038
    6. GSR was the most significant single SNP association with systemic lupus erythematosus in African Americans. PMID: 23637325
    7. The results demonstrate for the first time that glutathione reductase gene polymorphisms are significantly associated with bone mineral density. PMID: 22089180
    8. Up-regulation of CAT and GR activity resulted in an increase in total antioxidant activity in A549 after exposure to B(a)P. PMID: 21417634
    9. Human eye lenses were dissected into discrete regions that were formed at different stages of life and assayed for activity of lactate dehydrogenase (LDH) and a particularly stable enzyme, glutathione reductase (GR). PMID: 20586645
    10. novel glutathione reductase alternative splice variants PMID: 20628807
    11. GR deficiency and drug-induced GR inhibition may protect from malaria by inducing enhanced ring stage phagocytosis rather than by impairing parasite growth directly [case study] PMID: 19806191
    12. Malignant lung tumors (squamous cell carcinoma and adenocarcinoma) had increased activity of this enzyme. PMID: 12447480
    13. activities of catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were decreased during intense physical exercise PMID: 12516882
    14. An oxidative stress marker after kidney transplantation PMID: 12826156
    15. Patients with chronic alcoholism (PCA) of stage II have increased glutathione reductase (GR) activity in neutrophils, lymphocytes and monocytes compared with that in the cells of healthy donors PMID: 12838767
    16. GR activity in COPD and chest osteomyelitis decreased by 40% and more, lung tumors--by 32-36%. PMID: 12838770
    17. serum concentrations in patients with chronic lymphocytic leukemia PMID: 14637279
    18. Decreased activities of erythrocyte glutathione reductase is associated with cerebral palsy PMID: 15978628
    19. Data show that both glutathione and glutathione reductase are inducible by D3T, and that upregulation of GSH biosynthesis underlies D3T-mediated cytoprotection against ROS/RNS-elicited injury to human vascular smooth muscle cells. PMID: 17206382
    20. Inhibitory effects of several antibiotics on purified human erythrocyte glutathione reductase has been investigated. PMID: 18341267
    21. Data report synchrotron-based cryocrystallographic studies of natural substrate complexes of the flavoenzyme human glutathione reductase at nominal resolutions between 1.1 and 0.95 A that reveal new aspects of its mechanism. PMID: 18638483
    22. higher glutathione reductase and total antioxidant capacity were found in end-stage renal disease patients than in controls PMID: 19377255

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  • 亚细胞定位：
    [Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic]: Cytoplasm.
  • 蛋白家族：
    Class-I pyridine nucleotide-disulfide oxidoreductase family
  • 数据库链接：

    HGNC: 4623

    OMIM: 138300

    KEGG: hsa:2936

    STRING: 9606.ENSP00000221130

    UniGene: Hs.271510