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GSC Antibody

  • 货号：
    CSB-PA009950LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA009950LA01HU diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GSC Polyclonal antibody
  • Uniprot No.：
    P56915
  • 基因名：
    GSC
  • 别名：
    Goosecoid antibody; goosecoid homeobox antibody; GSC antibody; GSC_HUMAN antibody; Homeobox protein goosecoid antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein goosecoid protein (43-127AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GSC Antibody (CSB-PA009950LA01HU)，的标记方式是Non-conjugated。对于GSC Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA009950LB01HU GSC Antibody, HRP conjugated ELISA
    FITC CSB-PA009950LC01HU GSC Antibody, FITC conjugated
    Biotin CSB-PA009950LD01HU GSC Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.
  • 基因功能参考文献：
    1. Performed mutational analysis of TCOF1, GSC, and HOXA2 to determine the mutational features of the 3 genes in Chinese patients with Treacher Collins syndrome. PMID: 27526242
    2. We find that DIGIT is divergent to Goosecoid (GSC) and expressed during endoderm differentiation. Deletion of the SMAD3-occupied enhancer proximal to DIGIT inhibits DIGIT and GSC expression and definitive endoderm differentiation. PMID: 27705785
    3. 5 genomic variants in GSC, HOXA2 and PRKRA were identified through mutational analysis in Chinese patients with microtia. PMID: 28109504
    4. GSC is also a prognostic factor for poor survival and metastasis of HCC, which suggests its potential as a therapeutic target for metastatic HCC. PMID: 25343336
    5. Results suggest that GSC is the most potential biomarker of drug response and poor prognosis in ovarian serous carcinomas. PMID: 24858567
    6. EtOH exposure increased the expression of an organizer specific gene, goosecoid, in human embryonic carcinoma cells. PMID: 23378141
    7. SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid. PMID: 24290375
    8. GSC represses EVX1 expression and is required for development of anterior primitive-streak-like cell progeny in response to activin. PMID: 22178155
    9. The goosecoid gene mutation in exon 3 may be involved in the malformation events (microtia) in this family. PMID: 20195123
    10. Goosecoid promotes tumor cell malignancy and suggest that other conserved organizer genes may function similarly in human cancer PMID: 17142318
    11. GSC protein might contribute to the observed phenotype. PMID: 18074379

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  • 相关疾病：
    Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities (SAMS)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family, Bicoid subfamily
  • 数据库链接：

    HGNC: 4612

    OMIM: 138890

    KEGG: hsa:145258

    STRING: 9606.ENSP00000238558

    UniGene: Hs.440438