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GRM4 Antibody

  • 货号：
    CSB-PA693203
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR4 antibody.
    • Western blot analysis of extracts from 293 cells, untreated or treated with Forskolin (40nM, 30mins), using GluR4 antibody.
    • Western blot analysis of extracts from JK cells (Lane 2), using mGluR4 antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GRM4 Polyclonal antibody
  • Uniprot No.：
    Q14833
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human GluR4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
  • 基因功能参考文献：
    1. EGR1 and CTCF are probably involved in the transcriptional regulation of GRM4, which participates in the progress of osteosarcoma by interacting with chemokines and their receptors. PMID: 29339716
    2. Results suggest that variant rs2229901 of glutamate receptor 4 is associated with major depressive disorder risk. This variant probably impacts the interaction between GRM4 and miR-1202. PMID: 27792966
    3. Our data suggest that GRM4 gene polymorphism is closely related to the morbidity and metastasis of osteosarcoma in a Chinese population. PMID: 26276359
    4. The GRM4 gene polymorphism was associated with the susceptibility and metastasis of osteosarcoma in a Chinese Han population. PMID: 24984297
    5. study found that only one of the five SNPs tested showed a moderate but statistically significant association with juvenile myoclonic epilepsy in an Indian population PMID: 24840839
    6. The major depression subjects exhibited significantly higher expression level in the metabotropic receptor genes GRM4 in Locus coeruleus neurons. PMID: 24925192
    7. explored the relationship between the binding pockets of mGlu4-positive allosteric modulators with different chemical scaffolds and their functional properties PMID: 25342125
    8. Data show that mGlu2 and mGlu4 subunits (but not mGlu2 and mGlu1) can heteromerize. PMID: 20826542
    9. GRM4 sequence variants might confer low-risk effects to the etiology of idiopathic generalized epilepsies. PMID: 20338729
    10. residues shaping the binding pocket determine ligand selectivity for mGLUR4 PMID: 15184361
    11. mGluR4 has a role in 5-FU resistance in colonic neoplasms PMID: 15217955
    12. Results suggest that overexpression of mGluR4 is associated with poor prognosis. PMID: 15867225
    13. mGluR4 internalization and desensitization are agonist-independent unless pathways leading to the activation of PKC are induced. PMID: 16582932
    14. These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. PMID: 16899734
    15. the effects of P-Ser (inhibition of neural stem cell proliferation and self-renewal, enhanced neurogenic fate commitment, and improved neuronal survival) are mediated bymGluR4. PMID: 17884634

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 组织特异性：
    Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.
  • 数据库链接：

    HGNC: 4596

    OMIM: 604100

    KEGG: hsa:2914

    STRING: 9606.ENSP00000363296

    UniGene: Hs.429018