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GRIPAP1 Antibody

  • 货号：
    CSB-PA009923GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q4V328
  • 基因名：
  • 别名：
    DKFZp434P0630 antibody; DXImx47e antibody; GRAP1_HUMAN antibody; GRASP 1 antibody; GRASP-1 antibody; GRASP1 antibody; GRIP 1 associated protein 1 antibody; GRIP associated protein 1 antibody; GRIP1 associated protein 1 antibody; GRIP1-associated protein 1 antibody; GRIPAP 1 antibody; GRIPAP1 antibody; KIAA1167 antibody; MGC126593 antibody; MGC126595 antibody; MPMGp800B12492Q3 antibody; Sfc10 antibody; TAMALIN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GRIPAP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity.; Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.
  • 基因功能参考文献：
    1. We identified a new TFE3 fusion partner, GRIPAP1, in translocation renal cell carcinoma PMID: 28106924
    2. results demonstrate a requirement for normal recycling endosome function in AMPAR-dependent synaptic function and neuronal connectivity in vivo, and suggest a potential role for GRASP1 in the pathophysiology of human cognitive disorders. PMID: 28285821
    3. GRASP-1 was identified as an soluble autoantigen that has numerous coiled-coil domains throughout the protein. PMID: 15897011
    4. Results suggest that GRASP-1 serves as a scaffold protein to facilitate MEKK-1 activation of JNK signaling in neurons. PMID: 17761173
  • 亚细胞定位：
    Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse.
  • 数据库链接：

    HGNC: 18706

    OMIM: 300408

    KEGG: hsa:56850

    STRING: 9606.ENSP00000365624

    UniGene: Hs.109929