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GRIN3B Antibody

  • 货号：
    CSB-PA009917ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GRIN3B Polyclonal antibody
  • Uniprot No.：
    O60391
  • 基因名：
  • 别名：
    GluN3B antibody; Glutamate [NMDA] receptor subunit 3B antibody; Glutamate receptor ionotropic N methyl D aspartate 3B antibody; Glutamate receptor ionotropic NMDA 3B antibody; GRIN3B antibody; N-methyl-D-aspartate receptor subtype 3B antibody; NMD3B_HUMAN antibody; NMDA receptor subunit 3B antibody; NMDA type glutamate receptor subunit NR3B antibody; NMDAR3B antibody; NR3B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Glutamate receptor ionotropic, NMDA 3B protein (180-410AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
  • 基因功能参考文献：
    1. GRIN3B missense mutation is an inherited risk factor for schizophrenia. PMID: 28132660
    2. s investigated the significance of a common human genetic variation of the NMDAR NR3B subunit PMID: 25768306
    3. Rs2240158 of GRIN3B was significantly associated with mismatch negativity in healthy subjects. PMID: 24814139
    4. our findings suggest that the over-expression of NR3B subunit of NMDA receptor is a long lasting result of chronic opioid abuse. PMID: 20153313
    5. These observations suggest that the genetic variation of the NR3B subunit of the NMDA receptor is not a risk factor for Alzheimer's dis pathogenesis PMID: 20016182
    6. NR3B mRNA expression in the human hippocampal formation (CA1-CA4 and dentate gyrus) and adjacent neocortex may have implications for understanding the role of NMDA receptors for physiological and pathological processes in these forebrain regions. PMID: 15722182
    7. cross-talk between NR3B and NR4A receptors is a mechanism modulating the transcriptional activities of these orphan nuclear receptors PMID: 17543277
    8. We tested whether genetic dysfunction of GRIN3B is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). PMID: 17687115

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, NR3B/GRIN3B subfamily
  • 数据库链接：

    HGNC: 16768

    OMIM: 606651

    KEGG: hsa:116444

    STRING: 9606.ENSP00000234389

    UniGene: Hs.660378