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GRIN2D Antibody

  • 货号：
    CSB-PA008991
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O15399
  • 基因名：
  • 别名：
    EB11 antibody; estrogen receptor binding CpG island antibody; GluN2D antibody; Glutamate [NMDA] receptor subunit epsilon 4 antibody; Glutamate [NMDA] receptor subunit epsilon-4 antibody; Glutamate receptor ionotropic antibody; glutamate receptor ionotropic NMDA 2D antibody; Glutamate receptor, ionotropic, N-methyl D-aspartate 2D antibody; Grin2d antibody; N methyl D aspartate receptor subtype 2D antibody; N methyl d aspartate receptor subunit 2D antibody; N-methyl D-aspartate receptor subtype 2D antibody; NMDA 2D antibody; NMDAR2D antibody; NMDE4 antibody; NMDE4_HUMAN antibody; NR2D antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NMDAε4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.
  • 基因功能参考文献：
    1. This study found that NMDAR activation, NR2D in particular, is involved in human fetal lung fibroblast proliferation and collagen production through a potential ERK1/2-mediated mechanism. PMID: 28987794
    2. High GRIN2D expression is associated with colorectal cancer. PMID: 26943033
    3. This study showed that the higher GluN2D mRNA level in healthy but not in depressed pregnant women as compared to non-pregnant individuals. PMID: 28284346
    4. GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers PMID: 27616483
    5. After 7 days of chronic alcohol exposure, there are significant increases in mRNA expression of GRIN2D in cultured neurons derived from alcoholic subjects, but not in cultures from nonalcoholics. PMID: 22486492
    6. Absence of truncating mutation in GRIN1 and GRIN2D genes in patients with autism spectrum disorder and schizophrenia and controls. PMID: 22833210
    7. In microsatellite instable and microsatellite and chromosomally stable cancers, CIMP and BRAF/KRAS mutations are similarly distributed indicating common mechanisms of tumor initiation or progression in the molecular pathogenesis. PMID: 21915661
    8. data show that the NMDAR2D was specifically expressed in cultivated keratinocytes PMID: 16328341

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  • 相关疾病：
    Epileptic encephalopathy, early infantile, 46 (EIEE46)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, NR2D/GRIN2D subfamily
  • 数据库链接：

    HGNC: 4588

    OMIM: 602717

    KEGG: hsa:2906

    STRING: 9606.ENSP00000263269

    UniGene: Hs.445015