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GRIN2C Antibody

  • 货号：
    CSB-PA244200
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA244200(GRIN2C Antibody) at dilution 1/100, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q14957
  • 基因名：
  • 别名：
    GluN2C antibody; Glutamate [NMDA] receptor subunit epsilon-3 antibody; Glutamate Receptor Ionotropic N Methyl D Aspartate 2C antibody; Glutamate receptor ionotropic, NMDA 2C antibody; Glutamate receptor, ionotropic, N methyl D aspartate 2C antibody; Grin2c antibody; N Methly D Aspartate Receptor Channel Subunit Epsilon 3 antibody; N Methyl D Aspartate Receptor Subtype 2C antibody; N methyl D aspartate receptor subunit 2C antibody; N-methyl D-aspartate receptor subtype 2C antibody; NMDAR2C antibody; NMDE3_HUMAN antibody; NR2C antibody; OTTHUMP00000041930 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human GRIN2C
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:100-1:300
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning.
  • 基因功能参考文献：
    1. ultra-rare variants with loss of function (frameshift, nonsense or splice site) in NMDARs genes like GRIN2C and GRIN2D may contribute to possible risk of schizophrenia PMID: 29317596
    2. Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk. PMID: 26289945
    3. these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface PMID: 26229101
    4. The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2C. PMID: 24925192
    5. TNFalpha significantly upregulates NMDA-R2C mRNA expression, in differentiated, confluent, normal keratinocytes but not in involved or uninvolved psoriatic keratinocyte monolayers PMID: 24102971
    6. The s identified and cloned sequences of NMDA receptor subunits 2A, 2B, and 2C from rat. They characterized the properties of the receptors composed of heteromeric 1-2A and heteromeric 1-2C and found that the latter had reduced sensitivity to magnesium and smaller conductance compared to the former. PMID: 1350383
    7. Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes. PMID: 22833210

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, NR2C/GRIN2C subfamily
  • 组织特异性：
    Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
  • 数据库链接：

    HGNC: 4587

    OMIM: 138254

    KEGG: hsa:2905

    STRING: 9606.ENSP00000293190

    UniGene: Hs.436980