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GRIK4 Antibody

  • 货号：
    CSB-PA619054LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate
      All lanes: GRIK4 antibody at 2.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 108 kDa
      Observed band size: 97 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GRIK4 Polyclonal antibody
  • Uniprot No.：
    Q16099
  • 基因名：
  • 别名：
    EAA 1 antibody; EAA1 antibody; Excitatory amino acid receptor 1 antibody; GluK4 antibody; Glutamate receptor antibody; Glutamate receptor ionotropic kainate 4 antibody; Glutamate receptor ionotropic kainate 4 precursor antibody; Glutamate receptor KA 1 antibody; Glutamate receptor KA 1precursor antibody; Glutamate receptor KA-1 antibody; Glutamate receptor KA1 antibody; Glutamate receptor; ionotropic kainate 4 antibody; GRIK 4 antibody; GRIK antibody; Grik4 antibody; GRIK4_HUMAN antibody; ionotropic kainate 4 antibody; KA 1 antibody; KA1 antibody; OTTHUMP00000045951 antibody; OTTHUMP00000231881 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Glutamate receptor ionotropic, kainate 4 protein (826-956AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GRIK4 Antibody (CSB-PA619054LA01HU)，的标记方式是Non-conjugated。对于GRIK4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA619054LB01HU GRIK4 Antibody, HRP conjugated ELISA
    FITC CSB-PA619054LC01HU GRIK4 Antibody, FITC conjugated
    Biotin CSB-PA619054LD01HU GRIK4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
  • 基因功能参考文献：
    1. the GRIK4 polymorphisms genotypes were distributed as follows: rs79526501: CC696: 16, CG302: 274, GG31: 35; rs11218016: CC455: 483, CT473: 436, TT101: 108; and rs6589847: AA32: 29, AG307: 314, GG690: 686. However, there was no significant difference in allelic or genotypic frequency distributions between patients and controls. We did not find any significant association between GRIK4 polymorphisms and schizophrenia. PMID: 28658089
    2. Results firstly indicated that rs56275759 of GRIK4 gene might be associated with major depressive disorder in Chinese Han population. PMID: 28583584
    3. This study showed the lower GluK4 mRNA levels in pregnant women. PMID: 28284346
    4. Data suggest the involvement of glutamate receptor, ionotropic, kainate 4 protein (GRIK4) in treatment-resistant depression (TRD) and in the risk of developing psychotic symptoms during depressive episodes. PMID: 26139080
    5. Subjects possessing the C allele or CC genotype of the GRIK4 polymorphism rs1954787 are more likely to respond to antidepressant treatment. PMID: 25303296
    6. The deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells. PMID: 22052594
    7. Activation of kainate receptors could serve as a novel mechanism for enhancing B cell activation and immunoglobulin production. PMID: 21215464
    8. The GRIK4 single nucleotide polymorphism (rs12800734) shows a strong association with disease remission in antidepressant treatment. PMID: 19924111
    9. Cytogenetic and genetic findings provide molecular evidence for common etiologies for schizophrenia and and bipolar disorder and further support the 'glutamate hypothesis' of psychotic illness. PMID: 16819533
    10. An insertion/deletion (indel) variant in the 3' untranslated region (3'UTR) of the GRIK4 gene in subjects carrying the protective bipolar disorder haplotype was found. PMID: 18824690
    11. This report provides the first evidence that genetic variation in the GRIK4 gene modulates hippocampal function. PMID: 19384319

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK4 subfamily
  • 数据库链接：

    HGNC: 4582

    OMIM: 600282

    KEGG: hsa:2900

    STRING: 9606.ENSP00000404063

    UniGene: Hs.538738