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GRIK2 Antibody

  • 货号：
    CSB-PA413776
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Human Colon Tissue using GRIK2(GluR6) Rabbit pAb diluted at 1:200.
  • 其他：

产品详情

  • Uniprot No.：
    Q13002
  • 基因名：
  • 别名：
    bA487F5.1 antibody; EAA4 antibody; Excitatory amino acid receptor 4 antibody; GLR 6 antibody; GLR6 antibody; GluK2 antibody; GLUK6 antibody; GLUR 6 antibody; GluR-6 antibody; GluR6 antibody; Glutamate receptor 6 antibody; Glutamate receptor antibody; glutamate receptor form A antibody; glutamate receptor form B antibody; glutamate receptor form C antibody; glutamate receptor form D antibody; glutamate receptor form E antibody; Glutamate receptor ionotropic kainate 2 antibody; GRIK 2 antibody; GRIK2 antibody; GRIK2 protein antibody; GRIK2_HUMAN antibody; ionotropic kainate 2 antibody; MRT6 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic Peptide
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:100-200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2.; Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons.
  • 基因功能参考文献：
    1. results suggest that PKC SUMOylation is an important regulator of the 14-3-3 and GluK2a protein complex and may contribute to regulate the decay kinetics of kainate receptor-excitatory postsynaptic currents PMID: 28837400
    2. these findings indicate that GRIK2 has a role in the maintenance of urothelial cancer stem cells and that GRIK2 and ALDH1 can be prognosis prediction markers for urinary tract carcinomas PMID: 28418868
    3. TTBK2 down-regulates GluK2 activity by decreasing the receptor protein abundance in the cell membrane via RAB5-dependent endocytosis. PMID: 27607061
    4. In the Han population in Central China, the polymorphisms of SNP rs9390754 in the GRIK2 gene may be associated with epilepsy susceptibility. PMID: 27324535
    5. Study demonstrates that co-assembly of recombinant kainate receptors (GluK1 and GluK2) with the Neto1 and Neto2 auxiliary subunits alters their onset and recovery from desensitization in a subunit-dependent manner PMID: 26277340
    6. This study found in GRIK2 (glutamate receptor, ionotropic kainate 2) was most significant and also showed significant correlations with gene expression. PMID: 24662927
    7. This study showed that Gluk2 association with obsessive-compulsive disorder. PMID: 24821223
    8. Parkin interacts with the kainate receptor GluK2 subunit and regulates KAR function. PMID: 25316086
    9. High risk genetic markers of paranoid schizophrenia were GRIK2*ATG and GRIK2*TGG in Tatars. PMID: 25842862
    10. The present study reveals an additional mechanism for the regulation of GluK2-containing kainate receptors by Src family kinases, which may be of pathological significance in ischemic stroke. PMID: 25201974
    11. we found no association between rs1556995 in GRIK2 and clozapine-induced obsessive-compulsive (OC) symptoms, implying that that GRIK2 may not play a role in the development of OC symptoms in schizophrenia patients PMID: 23660601
    12. Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state. PMID: 23713029
    13. 14-3-3 proteins are an important regulator of GluK2a-containing KARs and may contribute to the slow decay kinetics of native KAR-EPSCs. PMID: 23861400
    14. Kainate receptor GluK2a post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis PMID: 23400781
    15. Eight chromosome 6 SNPs, having the most significant differences, were delineated: rs10499298, rs10499299, rs17827966, rs1224329, rs1150790, rs713050, rs2518344 and rs487083; all were associated with genes GRIK2. PMID: 23037145
    16. The ACAG haplotype in the 13th haplotype block of the GRIK2 gene was associated with somatic anxiety. PMID: 22429480
    17. Comprehensive analytical methods applied to a much larger sample than in previous studies do not support a role for GRIK2 as a genetic modifier of age at onset of clinical symptoms in Huntington's disease. PMID: 22771793
    18. Convergent functional genomics allowed the identification of novel candidate genes, GRIK2 and NPAS2, involved in glutamatergic neurotransmission and the circadian rhythm, respectively, that are potentially associated with CFS. PMID: 21912186
    19. Genotyping and linkage analysis excluded linkage of the GRIK2 gene and TUSC3 gene with mental retardation. PMID: 21557188
    20. This study supports previously reported findings of association between proximal GRIK2 single nucleotide polymorphism and obsessive-compulsive disorder in a comprehensive evaluation of the gene PMID: 20370803
    21. human GluK2 is a slowly activating channel but more sensitive to glutamate, as compared to the rat ortholog; the M867I mutation does not affect the rate the equilibrium constants of the channel opening but does slow down the channel desensitization rate PMID: 20863077
    22. Spliced variants of ionotropic glutamate receptor GluR6 is associated with astrocytoma. PMID: 20230879
    23. phosphorylation of PKC sites on GluR6 regulates surface expression of GluR6 at distinct intracellular trafficking pathways PMID: 19920140
    24. Linkage and association of the glutamate receptor 6 gene with autism PMID: 11920157
    25. Specific alleles in GluR6 and CA150 locus were only observed in HD patients. PMID: 12821179
    26. describes the time course of the open-channel form of the receptor as a function of glutamate concentration PMID: 14567698
    27. Using three single nucleotide polymorphisms in GRIK2 and one in GRIK3, we found no evidence for association with Obssessive-Compulsive disorder in case-control or family-based analyses. PMID: 15094479
    28. In this study, the maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia. PMID: 15305151
    29. The modifier effect is actually due to the TAA repeat itself, possibly via a functional consequence on the GRIK2 mRNA. PMID: 16959037
    30. Our data on altered functional properties of GluR6(M836I) provide a functional basis for the postulated linkage of GluR6 to autism. PMID: 17167233
    31. phosphorylation of the C-terminal tail of GluR6 by PKA leads to potentiation of whole cell response PMID: 17379418
    32. These results suggest a potential association between GRIK2 and autism in the Korean population. PMID: 17428563
    33. Mutations of GluR6 are unlikely to be associated with autism in the Indian population. PMID: 17712621
    34. report a complex mutation in the ionotropic glutamate receptor 6 gene (GRIK2, also called "GLUR6") that cosegregates with moderate-to-severe nonsyndromic autosomal recessive mental retardation in a large, consanguineous Iranian family PMID: 17847003
    35. Overall, our data indicate that hGluR6c might have unique properties in non-nervous cells and in the first stages of CNS development. PMID: 18289788
    36. the apo state of GluR6 undergoes a cleft closure of 29-30 degrees upon binding full agonists, one of the largest observed in the glutamate receptor family. PMID: 18658129
    37. Mutations to GLUR6 binding pocket that selectively affect domoate binding are freported. PMID: 18664604
    38. nonconserved residues in GluR6 define the size of the agonist-binding pocket, exerting a steric influence on the bound agonist and the extent of binding-domain closure PMID: 18690046
    39. GluR6 C-terminal domain KRIP6 regulates kainate receptors by inhibiting PICK1 modulation via competition or a mutual blocking effect PMID: 18692513
    40. in silico ligand-docking predicted that most partial agonists select for the closed and not, as expected, the open or intermediate conformations of the GluK2 agonist binding domain. PMID: 19225180
    41. Results indicate that ions can contribute substantial free energy to active state stabilization in GluR6, and provide quantitative measurements of the energetic consequences of allosteric ion binding to a ligand-gated ion channel. PMID: 19617541

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  • 相关疾病：
    Mental retardation, autosomal recessive 6 (MRT6)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK2 subfamily
  • 组织特异性：
    Expression is higher in cerebellum than in cerebral cortex.
  • 数据库链接：

    HGNC: 4580

    OMIM: 138244

    KEGG: hsa:2898

    STRING: 9606.ENSP00000397026

    UniGene: Hs.98262