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GRHPR Antibody

  • 货号：
    CSB-PA009897HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat liver tissue, Mouse liver tissue
      All lanes: GRHPR antibody at 3.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 36, 28 kDa
      Observed band size: 36 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA009897HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA009897HA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA009897HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GRHPR Polyclonal antibody
  • Uniprot No.：
    Q9UBQ7
  • 基因名：
    GRHPR
  • 别名：
    GLXR antibody; glycerate 2 dehydrogenase antibody; GLYD antibody; Glyoxylate reductase/hydroxypyruvate reductase antibody; Grhpr antibody; GRHPR_HUMAN antibody; OTTHUMP00000021379 antibody; OTTHUMP00000021380 antibody; OTTHUMP00000046131 antibody; PH 2 antibody; PH2 antibody; Primary hyperoxaluria type 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Glyoxylate reductase/hydroxypyruvate reductase protein (1-328AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GRHPR Antibody (CSB-PA009897HA01HU)，的标记方式是Non-conjugated。对于GRHPR Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA009897HB01HU GRHPR Antibody, HRP conjugated ELISA
    FITC CSB-PA009897HC01HU GRHPR Antibody, FITC conjugated
    Biotin CSB-PA009897HD01HU GRHPR Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
  • 基因功能参考文献：
    1. GRHPR was genotyped in Japanese patients with PH2 and all GRHPR mutations described to date were reviewed in terms of geographic and ethnic association PMID: 24116921
    2. Our findings suggest that the GRHPR defect in noncancerous tissues may represent an independent predictor of poor survival for hepatocellular carcinoma patients after curative resection PMID: 23486161
    3. GRHPR directly interacts with SVCT1. PMID: 23599041
    4. substrate specificity of human glyoxylate reductase PMID: 16756993
    5. the GRHPR gene may have a role in primary hyperoxaluria type 2 in a Japanese patient [case report] PMID: 17510093

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  • 相关疾病：
    Hyperoxaluria primary 2 (HP2)
  • 蛋白家族：
    D-isomer specific 2-hydroxyacid dehydrogenase family
  • 组织特异性：
    Ubiquitous. Most abundantly expressed in the liver.
  • 数据库链接：

    HGNC: 4570

    OMIM: 260000

    KEGG: hsa:9380

    STRING: 9606.ENSP00000313432

    UniGene: Hs.155742