Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. GPT2 Antibody

GPT2 Antibody

  • 货号：
    CSB-PA009865GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TD30
  • 基因名：
    GPT2
  • 别名：
    AAT2 antibody; Alanine aminotransferase 2 antibody; ALAT2_HUMAN antibody; ALT2 antibody; Glutamate pyruvate transaminase 2 antibody; Glutamic alanine transaminase 2 antibody; Glutamic pyruvate transaminase (alanine aminotransferase) 2 antibody; Glutamic pyruvic transaminase 2 antibody; Glutamic--alanine transaminase 2 antibody; Glutamic--pyruvic transaminase 2 antibody; GPT 2 antibody; gpt2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GPT2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
  • 基因功能参考文献：
    1. The GPT2 gene demonstrates increasing expression in brain in the early postnatal period, and GPT2 protein localizes to mitochondria. Akin to the human phenotype, Gpt2-null mice exhibit reduced brain growth. Through metabolomics and direct isotope tracing experiments, we find a number of metabolic abnormalities associated with loss of Gpt2 PMID: 27601654
    2. Recessively inherited loss of function GPT2 mutations are a novel cause of intellectual disability. PMID: 25758935
    3. ATF4 silencing prevented the activating effect of histidinol and tunicamycin on ATF4 and ALT2 expression. Our findings point to ALT2 as an enzyme involved in the metabolic adaptation of the cell to stress PMID: 24418603
    4. expression of GPT2 especially in muscle and fat, suggests a unique and previously unrecognized role of this gene product in glucose, amino acid, and fatty acid metabolism and homeostasis. PMID: 11863375
    5. The biliary IL-6 and TNF-alpha levels were positively correlated with serum DBIL, TBA and gamma-GT levels in infantile hepatitis syndrome subjects. PMID: 17109502
    6. Elevation of liver enzymes and hepatic insulin resistance as reflected by fasting insulin occur in the early stages of insulin resistance and highlight the central role of the liver in insulin resistance in the general population. PMID: 17596883
    7. A clinical method for selective measurement of ALT1 and 2 in human plasma is described. PMID: 19360321

    显示更多

    收起更多

  • 相关疾病：
    Mental retardation, autosomal recessive 49 (MRT49)
  • 蛋白家族：
    Class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily
  • 组织特异性：
    Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.
  • 数据库链接：

    HGNC: 18062

    OMIM: 138210

    KEGG: hsa:84706

    STRING: 9606.ENSP00000345282

    UniGene: Hs.460693