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GPR39 Antibody

  • 货号：
    CSB-PA009812LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA009812LA01HU at dilution of 1:100
    • Immunofluorescence staining of HepG2 cells with CSB-PA009812LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GPR39 Polyclonal antibody
  • Uniprot No.：
    O43194
  • 基因名：
  • 别名：
    GPR39; G-protein coupled receptor 39
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human G-protein coupled receptor 39 protein (345-453AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GPR39 Antibody (CSB-PA009812LA01HU)，的标记方式是Non-conjugated。对于GPR39 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA009812LB01HU GPR39 Antibody, HRP conjugated ELISA
    FITC CSB-PA009812LC01HU GPR39 Antibody, FITC conjugated
    Biotin CSB-PA009812LD01HU GPR39 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death.
  • 基因功能参考文献：
    1. data indicate that Zn(2+) acting via ZnR/GPR39 has a direct role in controlling Cl(-) absorption via upregulation of basolateral KCC1 in the colon. Moreover, colonocytic ZnR/GPR39 and KCC1 reduce water loss during diarrhea and may therefore serve as effective drug targets. PMID: 28093242
    2. G protein-coupled receptor 39 (ZnR/GPR39) was shown to regulate the activity of ion transport mechanisms that are essential for the physiological function of epithelial and neuronal cells [Review]. PMID: 29389900
    3. Data suggest that expression of GPR39 undergoes Rho kinase-dependent desensitization following activation by zinc. PMID: 28619258
    4. This study demonstrated that zinc upregulates PKCzeta by activating GPR39 to enhance the abundance of ZO-1, thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells. PMID: 28515165
    5. obestatin/GPR39 system in the pathogenesis and/or clinical outcome of human gastric adenocarcinomas and highlight the potential usefulness of GPR39 as a prognostic marker in gastric cancer. PMID: 26716511
    6. Chronic administration of many antidepressants induces GPR39 up-regulation, which suggests that the Zn(2+)-sensing receptor may be considered as a new target for drug development in the field of depression. PMID: 25490458
    7. Taken together, our results provided a novel regulatory mechanism for GPR39-1b in NTRS1 signaling. PMID: 24512471
    8. ZnR/GPR39-dependent expression of tight junctional proteins, thereby leading to formation of a sealed intestinal epithelial barrier. PMID: 24967969
    9. Data suggests alterations (down-regulation) of the GPR39 receptor and involvement of CREB-BDNF pathway, possibly triggered by GPR39, as a new pathomechanism of depression PMID: 24333148
    10. Zn(2+) -dependent activation of ZnR/GPR39 also enhances the expression of the Ca(2+) -binding protein S100A4 that is linked to invasion of prostate cancer cells. PMID: 24264723
    11. GPR39 was present in thyroid autoimmune disease, non-toxic nodular goiter and toxic nodular goiter at band p51(kDa). PMID: 23485550
    12. ZnR/GPR39 is tuned to sense physiologically relevant changes in extracellular pH that regulate ZnR-dependent signaling and ion transport activity PMID: 22879599
    13. GPR39 activation increased the expression of the anti-apoptotic protein clusterin in butyrate-treated cells. GPR39 mediates Zn2+-dependent cell growth. PMID: 22545109
    14. GPR39 plays an important tumorigenic role in the development and progression of esophageal squamous cell carcinoma. PMID: 21352519
    15. extracellular Zn(2+), either applied or released following injury, activates ZnR/GPR39 to promote signaling leading to epithelial repair PMID: 20522546
    16. Data show that Phe-V:13 can serve as an aromatic lock for the proposed active conformation of the Trp-VI:13 rotameric switch, being involved in the global movement of TM-V and TM-VI in 7TM receptor activation. PMID: 19920139
    17. GPR39 is probably not the obestatin receptor PMID: 16959833
    18. could activate GPR39 by high concentrations of Zn(2+), demonstrating cell surface expression of a functional receptor that could elicit a Ca(2+) response. PMID: 17054911
    19. GPR39 functions as a Gq-coupled Zn2+-sensing receptor PMID: 17885920
    20. GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor PMID: 18180304
    21. It is proposed that Zn2+ acts as an agonist for GPR39, not in the classical manner by directly stabilizing an active conformation of the transmembrane domain, but instead by binding to His17 and His19 in the extracellular domain. PMID: 18588883

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in many tissues, including the stomach, intestine and hypothalamus.
  • 数据库链接：

    HGNC: 4496

    OMIM: 602886

    KEGG: hsa:2863

    STRING: 9606.ENSP00000327417

    UniGene: Hs.432395