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GPN1 Antibody

  • 货号：
    CSB-PA009724GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9HCN4
  • 基因名：
    GPN1
  • 别名：
    ATP(GTP) binding protein antibody; ATPBD1A antibody; FLJ51176 antibody; GPN loop GTPase 1 antibody; GPN-loop GTPase 1 antibody; Gpn1 antibody; GPN1_HUMAN antibody; MBD2 interacting protein antibody; MBD2-interacting protein antibody; MBDin antibody; NTPBP antibody; RNA polymerase II associated protein 4 antibody; RPAP4 antibody; XAB1 antibody; XPA binding protein 1 antibody; XPA binding protein 1 GTPase antibody; XPA-binding protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GPN1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA.
  • 基因功能参考文献：
    1. Results show that Gpn1-inhibitable, nuclear polyubiquitination on lysine 216 regulates the half-life of Gpn3 by tagging it for proteasomal degradation. PMID: 29029378
    2. an acquired PDZ-binding motif in Gpn3 Q279* caused Gpn3 nuclear entry, and inhibited Gpn1 nuclear export and Gpn3-mediated RNAPII nuclear targeting. PMID: 28940195
    3. GPN1 gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
    4. Gpn1-Gpn3 interaction was essential to maintain steady-state protein levels of both GTPases PMID: 25241168
    5. A highly active, evolutionarily conserved nuclear export sequences in XAB1/Gpn1, was identified. PMID: 22796641
    6. Data show that GPN1/GPN3 define a new family of small GTPases that are specialized for the transport of RNA polymerase II into the nucleus. PMID: 21768307
    7. RPAP4/GPN1 is a member of a newly discovered GTPase family that contains a highly conserved GPN loop motif that is essential, along with its GTP-binding motifs, for nuclear localization of POLR2A/RPB1 in a process that also requires microtubule assembly PMID: 20855544
    8. relieves MBD2-mediated transcriptional repression and reactivates transcription from methylated promoters PMID: 12588985

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    GPN-loop GTPase family
  • 组织特异性：
    Expressed ubiquitously.
  • 数据库链接：

    HGNC: 17030

    OMIM: 611479

    KEGG: hsa:11321

    STRING: 9606.ENSP00000264718

    UniGene: Hs.18259