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GPM6B Antibody

  • 货号：
    CSB-PA614417LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA614417LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA614417LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GPM6B Polyclonal antibody
  • Uniprot No.：
    Q13491
  • 基因名：
    GPM6B
  • 别名：
    GPM6B; M6B; Neuronal membrane glycoprotein M6-b; M6b
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Neuronal membrane glycoprotein M6-b protein (1-64AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GPM6B Antibody (CSB-PA614417LA01HU)，的标记方式是Non-conjugated。对于GPM6B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA614417LB01HU GPM6B Antibody, HRP conjugated ELISA
    FITC CSB-PA614417LC01HU GPM6B Antibody, FITC conjugated
    Biotin CSB-PA614417LD01HU GPM6B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
  • 基因功能参考文献：
    1. Increase in the expression levels of mRNA and protein for the Gpm6B is associated with various types of gynaecological malignancy. PMID: 25113253
    2. Circulating levels of DR6 and Gpm6B correlate with breast cancer tumor grade. PMID: 24696529
    3. Data show the Differences in high resolution melting analysis in promoters of tumor markers neuronal membrane glycoprotein M6-B, melanoma antigen family A12 and immunoglobulin superfamily Fc receptor indicated invasiveness of hepatocellular carcinoma. PMID: 23950870
    4. Microarray expression analysis of GPM6B-depleted osteogenic human mesenchymal stem cells revealed significant changes in genes involved in cytoskeleton organization and biogenesis. PMID: 21638316
    5. it is unlikely that mutations in M6B have a role in Pelizaeus-Merzbacher-like syndrome, as examined in eight patients PMID: 15214007
    6. Data suggest that M6B regulates serotonin uptake by affecting cellular trafficking of the serotonin transporter. PMID: 18581270

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Myelin proteolipid protein family
  • 组织特异性：
    Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.
  • 数据库链接：

    HGNC: 4461

    OMIM: 300051

    KEGG: hsa:2824

    UniGene: Hs.495710