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GPA33 Antibody

  • 货号：
    CSB-PA857459EA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of MCF-7 cells with CSB-PA857459EA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, SH-SY5Y whole cell lysate
      All lanes: GPA33 antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 36 kDa
      Observed band size: 50 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA857459EA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GPA33 Polyclonal antibody
  • Uniprot No.：
    Q99795
  • 基因名：
  • 别名：
    A33 antibody; Cell surface A33 antigen antibody; Cell surface A33 antigen precursor antibody; Glycoprotein A33 (transmembrane) antibody; Glycoprotein A33 antibody; Gpa33 antibody; GPA33_HUMAN antibody; MGC129986 antibody; MGC129987 antibody; OTTHUMP00000032346 antibody; Transmembrane glycoprotein A33 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cell surface A33 antigen protein (22-235AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GPA33 Antibody (CSB-PA857459EA01HU)，的标记方式是Non-conjugated。对于GPA33 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA857459EB01HU GPA33 Antibody, HRP conjugated ELISA
    FITC CSB-PA857459EC01HU GPA33 Antibody, FITC conjugated
    Biotin CSB-PA857459ED01HU GPA33 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in cell-cell recognition and signaling.
  • 基因功能参考文献：
    1. A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma PMID: 28226180
    2. A33 expression is directly correlated to colorectal tumor differentiation. PMID: 27272411
    3. Data indicate that EpCAM- and A33-Exos were released from the apical and basolateral surfaces, respectively. PMID: 23230278
    4. Data indicate positive staining was observed for both A33 expression and KRN330 binding from patients biopsied on Day 8, 9 or 14 following initial dosing of 3 mg/kg. PMID: 23294608
    5. The A33-dependent incorporation of B5 into extracellular enveloped vaccinia virions is mediated through an interaction between their lumenal domains. PMID: 22623777
    6. Increased interaction between vaccinia virus proteins A33 and B5 is detrimental to infectious extracellular enveloped virion production. PMID: 22623782
    7. cloning, chromosomal localizations, exon-intron structures and transcription start sites - target gene for the intestine-specific homeobox transcription factor, CDX1. PMID: 12114523
    8. Regulation of A33 antigen expression by GKLF. PMID: 12853980
    9. This work has demonstrated that the antigen is both highly immobile and extremely persistent-retaining its surface localization for a turnover halflife of greater than 2 days. PMID: 18236042

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.
  • 数据库链接：

    HGNC: 4445

    OMIM: 602171

    KEGG: hsa:10223

    STRING: 9606.ENSP00000356842

    UniGene: Hs.651244