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GNAT3 Antibody

  • 货号:
    CSB-PA587164
  • 规格:
    ¥1100
  • 图片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA587164(GNAT3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA587164(GNAT3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

产品详情

  • Uniprot No.:
    A8MTJ3
  • 基因名:
    GNAT3
  • 别名:
    GDCA antibody; Ggust antibody; Gnat 3 antibody; GNAT3 antibody; GNAT3_HUMAN antibody; Gtn antibody; Guanine nucleotide binding protein alpha transducing 3 antibody; Guanine nucleotide binding protein G(t) subunit alpha 3 antibody; Guanine nucleotide-binding protein G(t) subunit alpha-3 antibody; Gustducin alpha 3 antibody; Gustducin alpha 3 chain antibody; Gustducin alpha-3 chain antibody
  • 宿主:
    Rabbit
  • 反应种属:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human GNAT3
  • 免疫原种属:
    Homo sapiens (Human)
  • 标记方式:
    Non-conjugated
  • 抗体亚型:
    IgG
  • 纯化方式:
    Antigen affinity purification
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式:
    Liquid
  • 应用范围:
    ELISA,IHC
  • 推荐稀释比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能:
    Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed,...显示更多
  • 基因功能参考文献:
    1. (GNAT3, 11 SNPs) gene, located within the 1-LOD support interval region for their association with MS and its related traits. Several SNPs were associated with MS and its related traits. Remarkably. PMID: 22456541
    2. The sweet taste receptors (alpha-gustducin and T1R3) are involved in glucose-stimulated secretion of GLP-1 and PYY. PMID: 21324568
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20858777
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20660057
    5. the alpha-subunit of the taste-specific G protein gustducin is expressed prominently in cells of the human colon PMID: 16728727
    6. Axonemal-associated localization within the midpiece and principal piece of human spermatozoa raises the possibility that this G protein alpha-subunit may process intracellular signals controlling sperm motility. PMID: 17021831

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  • 亚细胞定位:
    Cytoplasm. Note=Dual distribution pattern; plasmalemmal pattern with apical region localization and cytosolic pattern with localization throughout the cytoplasm.
  • 蛋白家族:
    G-alpha family, G(i/o/t/z) subfamily
  • 组织特异性:
    Expressed in taste buds (sensory organs of clustered epithelial cells) of the circumvallate and foliate papillae of the tongue at protein level. Expressed in enteroendocrine L cells of the gut. Detected also in spermatozoa.
  • 数据库链接:

    HGNC: 22800

    OMIM: 139395

    KEGG: hsa:346562

    STRING: 9606.ENSP00000381339

    UniGene: Hs.335049