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GMPS Antibody

  • 货号：
    CSB-PA009582ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: GMPS antibody at 2.69µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: HL60 whole cell lysate
      Lane 3: MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to Rabbit IgG at 1/10000 dilution
      Predicted band size: 77, 66 kDa
      Observed band size: 77 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA009582ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GMPS Polyclonal antibody
  • Uniprot No.：
    P49915
  • 基因名：
    GMPS
  • 别名：
    GATD7 antibody; Glutamine amidotransferase antibody; GMP synthase [glutamine hydrolyzing] antibody; GMP synthase [glutamine-hydrolyzing] antibody; GMP synthetase antibody; Gmps antibody; GUAA_HUMAN antibody; Guanine monophosphate synthase antibody; Guanine monphosphate synthetase antibody; Guanosine 5' monophosphate synthase antibody; MLL/GMPS fusion protein antibody; Testicular tissue protein Li 82 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human GMP synthase [glutamine-hydrolyzing] protein (394-693AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
  • 基因功能参考文献：
    1. Three genes-ATP6V1G1 in 9q32, GMPS in 3q25.31, and TBX5 in 12q24.21-exhibited concomitant hypermethylation and decreased expression. The i(12p)-positive cells displayed global hypomethylation of gene-poor regions on 12p, a footprint previously associated with constitutional and acquired gains of whole chromosomes as well as with X-chromosome inactivation in females PMID: 26890086
    2. Cytoplasmic sequestration of GMPS requires ubiquitylation by TRIM21. PMID: 24462112
  • 相关疾病：
    A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.
  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    HGNC: 4378

    OMIM: 600358

    KEGG: hsa:8833

    STRING: 9606.ENSP00000419851

    UniGene: Hs.591314