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GMPR2 Antibody

  • 货号：
    CSB-PA873740LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GMPR2 Polyclonal antibody
  • Uniprot No.：
    Q9P2T1
  • 基因名：
    GMPR2
  • 别名：
    GMPR2GMP reductase 2 antibody; GMPR 2 antibody; EC 1.7.1.7 antibody; Guanosine 5'-monophosphate oxidoreductase 2 antibody; Guanosine monophosphate reductase 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human GMP reductase 2 protein (1-366AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GMPR2 Antibody (CSB-PA873740LA01HU)，的标记方式是Non-conjugated。对于GMPR2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA873740LB01HU GMPR2 Antibody, HRP conjugated ELISA
    FITC CSB-PA873740LC01HU GMPR2 Antibody, FITC conjugated
    Biotin CSB-PA873740LD01HU GMPR2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
  • 基因功能参考文献：
    1. Loss of expression of GMPR2 and PPARalpha is associated with breast cancer basal phenotype; indicating that they may play a role in carcinogenesis. PMID: 23208589
    2. A single crystal structure of human GMPR type 2 with IMP and NADPH fortuitously captures three different states, each of which mimics a distinct step in the catalytic cycle of guanosine monophosphate reductase(GMPR). PMID: 22037469
    3. Data suggest the existence of two distinct types of human GMP reductase molecular species, which can be used to explain the bimodal saturation curve noted with purified human erythrocyte GMP reductase. PMID: 12009299
    4. GMPR2 is a novel human GMP reductase, and overexpression of GMPR2 can promote the monocytic differentiation of HL-60 leukemia cells. PMID: 12669231
  • 蛋白家族：
    IMPDH/GMPR family, GuaC type 1 subfamily
  • 组织特异性：
    Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 4377

    OMIM: 610781

    KEGG: hsa:51292

    STRING: 9606.ENSP00000392859

    UniGene: Hs.368855