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GLUD2 Antibody

  • 货号：
    CSB-PA009545ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Glutamate dehydrogenase 2, mitochondrial antibody at 4μg/ml
      Lane 1: Mouse brain tissue
      Lane 2: 293T whole cell lysate
      Lane 3: Rat brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 61 kDa
      Observed band size: 61 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA009545ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GLUD2 Polyclonal antibody
  • Uniprot No.：
    P49448
  • 基因名：
  • 别名：
    DHE4_HUMAN antibody; GDH 2 antibody; GDH antibody; GDH2 antibody; GLUD2 antibody; GLUDP1 antibody; Glutamate dehydrogenase 2 antibody; Glutamate dehydrogenase 2 mitochondrial antibody; Glutamate dehydrogenase pseudogene 1 antibody; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Glutamate dehydrogenase 2, mitochondrial protein (319-558AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
  • 基因功能参考文献：
    1. hGDH2 evolution bestowed large human neurons with enhanced glutamate metabolizing capacity, thus strengthening cortical excitatory transmission. PMID: 26399640
    2. This study demonstrated that hGDH2 expression increases capacity for uptake and oxidative metabolism of glutamate, particularly during increased workload and hypoglycemia. PMID: 28032919
    3. This proliferation requires glutamate dehydrogenase 2, which synthesizes glutamate from ammonia and alpha-ketoglutarate and is expressed in MCF7 and T47D cells. Our findings provide insight into how cancer cells survive under glutamine deprivation conditions and thus contribute to elucidating the mechanisms of tumor growth. PMID: 29146184
    4. The expression of GLUD2 was identified in the cellular and subcellular compartments of numerous tissues. PMID: 27422263
    5. Notably, the introduction of GLUD2 did not affect glutamate levels in mice, consistent with observations in the primates. Instead, the metabolic effects of GLUD2 center on the tricarboxylic acid cycle, suggesting that GLUD2 affects carbon flux during early brain development, possibly supporting lipid biosynthesis. PMID: 27118840
    6. IDH1(R132H) exhibits a growth-inhibitory effect that is abrogated in the presence of glutamate dehydrogenase 2 (GLUD2), a hominoid-specific enzyme purportedly optimized to facilitate glutamate turnover in human forebrain. PMID: 25225364
    7. hGDH2 can operate efficiently in the relatively acidic environment that prevails in astrocytes following glutamate uptake [review] PMID: 24352816
    8. [review] Whereas GDH2 in most mammals is encoded by a single functional GLUD1 gene expressed widely, humans have acquired through retroposition an X-linked GLUD2 gene that encodes a highly homologous isoenzyme GDH2 expressed in testis and brain. PMID: 21420458
    9. GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells PMID: 20194501
    10. A gain-of-function rare polymorphism in hGDH2 hastens the onset of Parkinson's disease in hemizygous subjects. PMID: 19826450
    11. amino acid changes, acting in concert with Arg443Ser and Gly456Ala, ought to be responsible the unique properties of the brain-specific human isoenzyme PMID: 17924438
    12. Mitochondrial targeting specificity of GLUD2 is due to an amino acid substitution in the mitochondrial targeting sequence soon after the duplication event in the hominoid ancestor approximately 18-25 million years ago. PMID: 18688271
    13. study of molecular mechanisms regulating hGDH2 function by creating & analyzing mutants with single amino acid substitutions in the regulatory domain (antenna, pivot helix) of the protein PMID: 19393024
    14. GDH2 localizes mainly to mitochondria and to a lesser extent to the endoplasmic reticulum of cells PMID: 19428807

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  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Glu/Leu/Phe/Val dehydrogenases family
  • 组织特异性：
    Expressed in retina, testis and, at a lower level, brain.
  • 数据库链接：

    HGNC: 4336

    OMIM: 300144

    KEGG: hsa:2747

    STRING: 9606.ENSP00000327589

    UniGene: Hs.368538