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GLDC Antibody

  • 货号：
    CSB-PA328400LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA328400LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GLDC Polyclonal antibody
  • Uniprot No.：
    P23378
  • 基因名：
    GLDC
  • 别名：
    GCE antibody; GCSP antibody; GCSP_HUMAN antibody; GLDC antibody; Glycine cleavage system P protein antibody; glycine cleavage system protein P antibody; Glycine decarboxylase antibody; glycine decarboxylase P protein antibody; Glycine dehydrogenase (decarboxylating) mitochondrial antibody; Glycine dehydrogenase [decarboxylating]; mitochondrial antibody; Gycine dehydrogenase (decarboxylating) antibody; HYGN1 antibody; MGC138198 antibody; MGC138200 antibody; NKH antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Glycine dehydrogenase (decarboxylating), mitochondrial protein (868-984AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，GLDC Antibody (CSB-PA328400LA01HU)，的标记方式是Non-conjugated。对于GLDC Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA328400LB01HU GLDC Antibody, HRP conjugated ELISA
    FITC CSB-PA328400LC01HU GLDC Antibody, FITC conjugated
    Biotin CSB-PA328400LD01HU GLDC Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).
  • 基因功能参考文献：
    1. A novel compound heterozygous variant was identified in the GLDC gene in a Chinese family with non-ketotic hyperglycinemia PMID: 29304759
    2. it was concluded that elevated serum GLDC may increase lung cancer risk, and that smoking, GLDC, the miR29 family and DNMT signaling pathways may serve an important role in early malignant transformation during the development of lung cancer. PMID: 29956770
    3. a comprehensive functional and structural analysis of 19 GLDC missense variants identified in a cohort of 26 nonketotic hyperglycinemia patients was performed PMID: 28244183
    4. The position and frequency of the breakpoint for CNVs correlated with intron size and presence of Alu elements. Missense mutations, most often recurring, were the most common type of disease-causing mutation in AMT PMID: 27362913
    5. We show that the combination of GLDC and HIF-1alpha expression is an independent prognostic factor in early-stage lung non-small cell cancer PMID: 28062918
    6. study reports a novel mutation, c.2296G>T (p.Gly766Cys), in exon 19 of the glycine decarboxylase (GLDC) gene in a consanguineous Indian couple with a history of 4 neonatal deaths PMID: 23349517
    7. Identification of a splice acceptor site mutation and five different non-synonymous variants in GLDC were found in patients with neural tube defects. PMID: 22171071
    8. Study shows that glycine metabolism and the metabolic enzyme glycine decarboxylase (GLDC) drive tumor-initiating cells and tumorigenesis in non-small cell lung cancer. PMID: 22225612
    9. Heterozygous GLDC gene mutation in transient neonatal hyperglycinemia. PMID: 12402263
    10. Missense and nonsense mutations found in glycine encephalopathy PMID: 14552331
    11. Three adults with mild hyperglycinemia, infantile hypotonia, mental retardation, behavioral hyperirritability, and aggressive outbursts were screened for glycine decarboxylase mutations; two novel missense mutations were found. PMID: 15824356
    12. The mutation in this nonketotic hyperglycinemia kindred led to missplicing and reduced GLDC (glycine decarboxylase) expression. PMID: 15851735
    13. Single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is associated with glycine encephalopathy PMID: 15864413
    14. the nonketotic hyperglycinemia is due to a novel GLDC mutation. PMID: 16404748
    15. forty different gene alterations in the GLDC gene were identified in patients with glycine encephalopathy PMID: 16601880
    16. A screening system for GLDC deletions by multiplex ligation-dependent probe amplification identified 14 deletions of different length & Alu-mediated recombination in non-ketotic hyperglycinaemia patients. PMID: 17361008
    17. a histidine-to-aspartic acid change at amino acid position 371 (p. His371Asp mutation) in the glycine decarboxylase in a non-ketotic hyperglycemia patient. PMID: 18581728

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  • 相关疾病：
    Non-ketotic hyperglycinemia (NKH)
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    GcvP family
  • 数据库链接：

    HGNC: 4313

    OMIM: 238300

    KEGG: hsa:2731

    STRING: 9606.ENSP00000370737

    UniGene: Hs.584238