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GIPC1 Antibody

  • 货号：
    CSB-PA009435GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14908
  • 基因名：
    GIPC1
  • 别名：
    GIPC1 antibody; C19orf3 antibody; GIPC antibody; RGS19IP1PDZ domain-containing protein GIPC1 antibody; GAIP C-terminus-interacting protein antibody; RGS-GAIP-interacting protein antibody; RGS19-interacting protein 1 antibody; Synectin antibody; Tax interaction protein 2 antibody; TIP-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human GIPC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in G protein-linked signaling.
  • 基因功能参考文献：
    1. Upregulated expression of GIPC1 is associated with glioma. PMID: 27481513
    2. Drd3 palmitoylation acts as a molecular switch for Drd3-biased signaling via a GIPC1-dependent route, which is likely to affect the mode of action of antipsychotic drugs. PMID: 26787837
    3. The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment. PMID: 26757732
    4. GIPC status determines the loading of cellular cargo in the exosome in pancreatic cancer cells. PMID: 25469510
    5. GIPC binds LPA(1) and promotes its trafficking from APPL-containing signaling endosomes to EEA1 early endosomes and thus attenuates LPA-mediated Akt signaling from APPL endosomes. PMID: 23145131
    6. Our results do not show a predictive or prognostic function of GIPC1/Synectin expression for the outcome of radiotherapy in prostate cancer. PMID: 23128896
    7. a novel non-Smad function for endoglin and GIPC in regulating endothelial cell function during angiogenesis PMID: 22593212
    8. The placental lectins reduced the binding of IGF-I to IGF-1 receptor in a dose-dependent manner. PMID: 22082268
    9. Knockdown of ADRM1 in amplified ovarian cell-line OAW42 results in downregulation of growth factor GIPC1 and upregulation of tumor-suppressor RECK RNA and protein PMID: 21432940
    10. GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells PMID: 21209904
    11. interactions between TRP1-GIPC and GIPC-APPL-AKT provide a potential link between melanogenesis and PI3 kinase signaling PMID: 21291857
    12. aim was to evaluate associations with albuminuria of six GLUT1 single nucleotide polymorphisms(SNPs), particularly XbaI and the previously associated Enhancer-2 (Enh2) SNP PMID: 21247498
    13. Findings show the importance of GIPC in breast tumor progression. PMID: 21047775
    14. GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion. PMID: 20634288
    15. Among several HBc-interacting partners selected, it interacted most strongly with the human protein GIPC1. PMID: 20091192
    16. Data show that downregulation of myosin VI expression results in a significant reduction in PSA and VEGF secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI-interacting proteins, GIPC and LMTK2 and Dab2. PMID: 19855435
    17. The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits. PMID: 11852236
    18. expression of human GIPC1 mRNA in normal tissues, cancer cell lines, and primary tumors PMID: 11956658
    19. GIPC can regulate beta1-adrenergic receptor-stimulated, Gi-mediated, ERK activation while having no effect on receptor internalization or Gs-mediated cAMP signaling PMID: 12724327
    20. responsible for the recycling of the hormone that is internalized by the lutropin receptor and also for maintaining a relatively constant level of lutropin receptor at the cell surface during hormone internalization PMID: 14507927
    21. results support the notion that human papillomavirus type 18 E6 protein renders cells less sensitive to the cytostatic effect of TGF-beta by lowering the intracellular amount of TIP-2/GIPC PMID: 15767424
    22. These results suggest that caveolae could represent an intracellular site that contributes to differentiate IR and IGF-IR activity, and demonstrate the role of caveolin-1 in the eNOS activation by Insulin and IGF-I. PMID: 16225848
    23. GIPC can bind to itself and that the PDZ domain is involved in GIPC-GIPC interaction PMID: 16962991
    24. Targeting GIPC could be a promising new treatment option for pancreatic cancer. PMID: 18314626
    25. GIPC1 protein is overexpressed in ovarian and breast cancer PMID: 18721484
    26. GIPC1 is a novel breast cancer-associated immunogenic antigen that is overexpressed in breast cancer PMID: 18721486
    27. Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC PMID: 18775991
    28. the C-terminal PDZ-binding motif of Glut1 plays a key role in growth factor regulation of glucose uptake by both allowing GIPC to promote Glut1 trafficking to the cell surface and protecting intracellular Glut1 from lysosomal degradation. PMID: 19016655

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    GIPC family
  • 组织特异性：
    Widely expressed. Expressed in skeletal muscle (at protein level).
  • 数据库链接：

    HGNC: 1226

    OMIM: 605072

    KEGG: hsa:10755

    STRING: 9606.ENSP00000340698

    UniGene: Hs.655012